2-Aminoethylmethyl-sulfone (AEMS): a potent stimulator of ATP-dependent calcium uptake.
作者信息
Liebowitz S M, Lombardini J B, Allen C I
出版信息
Eur J Pharmacol. 1986 Jan 14;120(1):111-3. doi: 10.1016/0014-2999(86)90648-5.
PMID:3948910
Abstract
Retinal ATP-dependent calcium ion uptake is stimulated by a number of agents, but none are previously reported to be as potent as taurine. We have evaluated the effects of 2-aminoethylmethyl-sulfone (AEMS), thiomorpholine-1,1-dioxide (TMS), and N-methyl-thiomorpholine-1,1-dioxide (M-TMS) on calcium ion uptake. AEMS is twice as potent a stimulator of calcium ion uptake compared to taurine. TMS and M-TMS did not stimulate calcium ion uptake at concentrations up to 20 mM. These data demonstrate that the sulfonic acid moiety can be replaced by a methyl sulfone moiety for stimulation of ATP-dependent calcium ion uptake.
摘要
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