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2-氨基乙磺酸(牛磺酸)和氨基甲磺酸对大鼠视网膜制剂中钙离子摄取的相反作用。

Opposite effects of 2-aminoethanesulfonic acid (taurine) and aminomethanesulfonic acid on calcium ion uptake in rat retinal preparations.

作者信息

Lombardini J B

出版信息

Eur J Pharmacol. 1985 Apr 16;110(3):385-7. doi: 10.1016/0014-2999(85)90570-9.

Abstract

It is well known that taurine stimulates ATP-dependent calcium ion uptake at low calcium ion concentrations. However, aminomethanesulfonic acid, the lower homologue of taurine, inhibits calcium ion uptake under the same experimental conditions. The higher homologue of taurine, 3-aminopropanesulfonic acid, has no effect on calcium ion uptake. These data demonstrate that the carbon chain length between the amino and sulfonic acid moieties is critical for the resultant effect on the calcium ion transport process.

摘要

众所周知,在低钙离子浓度下,牛磺酸会刺激依赖ATP的钙离子摄取。然而,牛磺酸的低级同系物氨基甲磺酸在相同实验条件下会抑制钙离子摄取。牛磺酸的高级同系物3-氨基丙烷磺酸对钙离子摄取没有影响。这些数据表明,氨基和磺酸部分之间的碳链长度对于对钙离子转运过程产生的最终影响至关重要。

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