National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/ National Center of Gerontology, PR China; Chinese Academy of Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, PR China.
National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/ National Center of Gerontology, PR China; Chinese Academy of Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, PR China.
Clin Biochem. 2024 Dec;133-134:110839. doi: 10.1016/j.clinbiochem.2024.110839. Epub 2024 Nov 1.
Cystatin C (CysC) belongs to the cysteine protease inhibitor superfamily and is produced by all nucleated cells in the body in very stable amounts independent of age, sex, diet, and muscle mass. CysC is considered an ideal biomarker for assessing glomerular filtration rate (GFR) compared to traditional biomarkers for assessing GFR, such as creatinine. However, CysC is not sufficiently utilized for GFR assessment by clinicians, probably for various reasons such as insufficient understanding among clinicians or a lack of standardized quantitative methods. This review discusses and analyzes the aforementioned issues from the perspective of laboratory technicians.
胱抑素 C（CysC）属于半胱氨酸蛋白酶抑制剂超家族，由体内所有有核细胞以非常稳定的量产生，与年龄、性别、饮食和肌肉量无关。与评估肾小球滤过率（GFR）的传统生物标志物（如肌酐）相比，CysC 被认为是一种理想的生物标志物。然而，临床医生并未充分利用 CysC 来评估 GFR，原因可能是临床医生对此了解不足或缺乏标准化的定量方法等。本综述从实验室技术人员的角度讨论和分析了上述问题。
