Morrey B F, Dunn J M, Heimbach R D, Davis J
Clin Orthop Relat Res. 1979 Oct(144):121-7.
Forty patients with chronic osteomyelitis were treated with hyperbaric oxygen as an adjunct to surgical therapy and antibiotics and followed for an average of 2 years with a recurrence rate of 15%. The mechanism of action of hyperbaric oxygen in osteomyelitis is probably an indirect one of improving local vascularity and potentiating phagocytosis. Many of these patients represent a refractory group with poor prognosis due to the etiology of the infection, site of involvement, and duration of infection prior to treatment. The recurrence rate following this mode of treatment seems to be primarily related to inadequate surgical management. There was no definite correlation between the site of the infection of pathologic organism and recurrence. Although this is a preliminary report, the results are encouraging. Hyperbaric oxygen may be indicated as an adjunct to good surgical and medical management, particularly in patients with refractory chronic osteomyelitis and in whom ablative surgery is under consideration as the only other means of controlling the infection.
40例慢性骨髓炎患者接受高压氧治疗，作为手术治疗和抗生素治疗的辅助手段，并进行了平均2年的随访，复发率为15%。高压氧治疗骨髓炎的作用机制可能是间接的，即改善局部血管供应并增强吞噬作用。由于感染的病因、受累部位以及治疗前感染的持续时间，这些患者中有许多属于预后不良的难治性群体。这种治疗方式后的复发率似乎主要与手术处理不充分有关。感染部位或致病微生物与复发之间没有明确的相关性。虽然这是一份初步报告，但结果令人鼓舞。高压氧可作为良好手术和药物治疗的辅助手段，特别是对于难治性慢性骨髓炎患者以及那些考虑将切除手术作为控制感染的唯一其他手段的患者。
