水飞蓟宾对Fe2+-ADP和叔丁基过氧化氢诱导的微粒体脂质过氧化的差异作用。
Differential effect of silybin on the Fe2+-ADP and t-butyl hydroperoxide-induced microsomal lipid peroxidation.
作者信息
Valenzuela A, Guerra R
出版信息
Experientia. 1986 Feb 15;42(2):139-41. doi: 10.1007/BF01952435.
PMID:3948968
Abstract
We have observed a differential effect of silybin dihemisuccinate on rat liver microsomal oxygen consumption and on lipid peroxidation induced by NADPH-Fe2+-ADP and t-butyl hydroperoxide. These results are ascribed to the antioxidant properties of the flavonoid. The differences observed in the effect of the catalysts may be a consequence of the different capacity of silybin to act as a scavenger of free radicals formed by NADPH-Fe2+-ADP or t-butyl hydroperoxide.
摘要
我们观察到水飞蓟宾二半琥珀酸酯对大鼠肝脏微粒体氧消耗以及由NADPH - Fe2+ - ADP和叔丁基过氧化氢诱导的脂质过氧化有不同的作用。这些结果归因于该类黄酮的抗氧化特性。在催化剂作用方面观察到的差异可能是由于水飞蓟宾作为由NADPH - Fe2+ - ADP或叔丁基过氧化氢形成的自由基清除剂的能力不同所致。
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