Kelestimur Fahrettin, Ioachimescu Adriana G
Division of Endocrinology, Yeditepe University, Medical School, İstanbul, Türkiye.
Departments of Medicine and Neurosurgery, Division of Endocrinology and Molecular Medicine, Medical College of Wisconsin, Wisconsin, USA.
Rev Endocr Metab Disord. 2024 Dec;25(6):941-942. doi: 10.1007/s11154-024-09921-w. Epub 2024 Nov 4.
This special issue of Reviews in Endocrine and Metabolic Disorders is dedicated to hypoprolactinemia. Prolactin is known for its actions on the mammary gland including development, preparation for postpartum lactation, as well as synthesis and maintenance of milk secretion. However, prolactin has many other physiological effects on reproduction, embryonic and fetal development, homeostasis, neuroprotection, behavior, and immunoregulation. In clinical practice, physiopathology and clinical consequences of increased prolactin secretion are generally well understood, and medical treatment to decrease prolactin levels is available and effective in most cases. Unlike prolactin excess, hypoprolactinemia has been a neglected endocrine disorder and nospecific replacement therapy is commercially available. Prolactin is the only anterior pituitary hormone not addressed by clinical hypopituitarism guidelines. In recent years, human studies have revealed that hypoprolactinemia is associated with metabolic, sexual and neuropsychologic alterations. Therefore, this special issue of Reviews in Endocrine and Metabolic Disorders is aimed to enhance our incomplete understanding of hypoprolactinemia. A total of 17 articles were authored by respected scientists and clinicians from a variety of disciplines including adult and pediatric endocrinology, pathology, gynecology, reproductive medicine, oncology, and neurosurgery.
《内分泌与代谢疾病评论》的这一特刊致力于探讨低催乳素血症。催乳素以其对乳腺的作用而闻名，包括乳腺发育、产后泌乳准备以及乳汁分泌的合成与维持。然而，催乳素在生殖、胚胎和胎儿发育、体内平衡、神经保护、行为及免疫调节等方面还有许多其他生理作用。在临床实践中，催乳素分泌增加的生理病理学及临床后果通常已得到充分理解，且在大多数情况下，降低催乳素水平的药物治疗是可行且有效的。与催乳素过多不同，低催乳素血症一直是一种被忽视的内分泌疾病，目前尚无商业化的特异性替代疗法。催乳素是临床垂体功能减退指南未涉及的唯一一种垂体前叶激素。近年来，人体研究表明，低催乳素血症与代谢、性及神经心理改变有关。因此，《内分泌与代谢疾病评论》的这一特刊旨在加深我们对低催乳素血症尚不完整的认识。共有17篇文章由来自包括成人及儿科内分泌学、病理学、妇科、生殖医学、肿瘤学和神经外科等多个学科的知名科学家和临床医生撰写。
