Dmitrenko N P, Goroshnikova T V
Farmakol Toksikol. 1986 Jan-Feb;49(1):59-62.
It was shown that dipyridamole and papaverine induce concentration-dependent inhibition of the absorption of [14C] adenosine by thymocytes. This action is different in lymphocytes from different lymphoid organs and blood. Dipyridamole enhances the effect of various papaverine concentrations on the absorption of adenosine by thymocytes, but it does not exceed the maximal effect, achieved by the latter in high doses. It is supposed, that dipyridamole inhibits the cell transport of adenosine and papaverine influences the adenine-nucleotide metabolism.
结果表明,双嘧达莫和罂粟碱可浓度依赖性地抑制胸腺细胞对[14C]腺苷的吸收。这种作用在来自不同淋巴器官和血液的淋巴细胞中有所不同。双嘧达莫可增强不同浓度罂粟碱对胸腺细胞吸收腺苷的作用,但不超过后者高剂量时所达到的最大作用。据推测,双嘧达莫抑制腺苷的细胞转运,而罂粟碱影响腺嘌呤核苷酸代谢。