Institute of Biological Sciences, Faculty of Exact and Natural Sciences, University of Siedlce, 14 Bolesława Prusa Str., 08-110 Siedlce, Poland.
Department of Ichthyology and Biotechnology in Aquaculture, Institute of Animal Science, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, Poland.
Animal. 2024 Nov;18(11):101345. doi: 10.1016/j.animal.2024.101345. Epub 2024 Sep 26.
Klebsiella pneumoniae, common pathogenic bacteria, cause dangerous infectious diseases in animals and humans. Klebsiella pneumoniae have numerous resistance mechanisms to antibacterials and the frequency of resistant K. pneumoniae isolates increases, making treatment of K. pneumoniae-induced infections difficult. Farm animals are a possible source of antibacterial resistant K. pneumoniae. The aim of this literature review (2018-2024) was to evaluate the antibacterial resistance of K. pneumoniae isolated from poultry, cattle and pigs in various countries. The analysis shows that farm animals are an important source of antibacterial-resistant and multidrug-resistant K. pneumoniae and that resistance patterns differ among antibacterial groups, animals and locations. In poultry, high resistance to penicillins (91%), III and IV generation cephalosporins (> 50%) occurred, and low to carbapenems (5%) and polymyxins (6%). In cattle, high resistance to sulphonamides (76%), IV generation cephalosporins, macrolides and lincosamides, and penicillins occurred (> 50%), and low to carbapenems (10%) and polymyxins (1%). Isolates from pigs showed high resistance to I and II-generation cephalosporins, I-generation fluoroquinolones, macrolides and lincosamides, tetracyclines (> 50%) and carbapenems (> 20%), and low to polymyxins (5%). The highest resistance rates to most antibacterial groups occurred in pigs, and in Africa and Asia, while the lowest in cattle, and in North and South America. Particularly, the relatively high resistance of K. pneumoniae to carbapenems and polymyxins in Africa poses a threat to animal and human health as these antibiotics are the last resort therapeutics used to treat severe infections. Different rates of K. pneumoniae resistance to antibacterials among isolates from farm animals probably result from differences in the treatment of each animal group with various antibacterial agents and different regimes of their use in various locations.
肺炎克雷伯菌是一种常见的致病性细菌，可导致动物和人类发生危险的传染病。肺炎克雷伯菌对抗菌素有多种耐药机制，耐药肺炎克雷伯菌分离株的频率增加，使肺炎克雷伯菌感染的治疗变得困难。农场动物可能是携带抗菌耐药肺炎克雷伯菌的一个来源。本文献综述（2018-2024 年）的目的是评估来自不同国家的家禽、牛和猪的肺炎克雷伯菌的抗菌耐药性。分析表明，农场动物是抗菌耐药和多药耐药肺炎克雷伯菌的重要来源，并且耐药模式在不同抗菌药物组、动物和地点之间存在差异。在家禽中，青霉素（91%）、三代和四代头孢菌素（>50%）耐药率高，对碳青霉烯类（5%）和多黏菌素（6%）耐药率低。在牛中，磺胺类（76%）、四代头孢菌素、大环内酯类和林可酰胺类以及青霉素耐药率高（>50%），对碳青霉烯类（10%）和多黏菌素（1%）耐药率低。猪分离株对一、二代头孢菌素、一代氟喹诺酮类、大环内酯类和林可酰胺类、四环素（>50%）和碳青霉烯类（>20%）耐药率高，对多黏菌素（5%）耐药率低。大多数抗菌药物组的耐药率在猪中最高，在非洲和亚洲，在牛中最低，在北美和南美。特别是，非洲肺炎克雷伯菌对碳青霉烯类和多黏菌素的相对较高耐药性对动物和人类健康构成威胁，因为这些抗生素是治疗严重感染的最后手段。农场动物分离株对抗菌药物的耐药率不同，可能是由于对不同动物群体使用各种抗菌药物的治疗方法不同，以及在不同地点使用这些药物的方案不同所致。
