Li Yanan, Ma Tianwen, Lv Xiaoping, Qiu Zongsheng, Li Shuxin, Qi Jingjing, Wei Chengwei
Heilongjiang Key Laboratory of Animal Disease Pathogenesis and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
Heilongjiang Key Laboratory of Animal Disease Pathogenesis and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China; Animal Clinical Teaching Hospital, Northeast Agricultural University, Harbin, China.
Poult Sci. 2024 Dec;103(12):104408. doi: 10.1016/j.psj.2024.104408. Epub 2024 Oct 10.
Fluoride is one of the essential trace elements for body. However, excessive fluoride poses a major threat to human and animal health. Fluorosis may cause pathological damage of the duodenum, but the underlying mechanism needs to be further studied. This study was to investigate the effects of long-term exposure to sodium fluoride (0, 500, 1,000, 2,000 mg/kg) on the duodenum of chickens. The results showed that after NaF exposure, intestinal epithelial cells were disarranged, necrotic or even exfoliated, goblet cells and mucus secretion were increased, and inflammatory response was induced in duodenal tissue. Oxidative stress, endoplasmic reticulum stress (ERs), and heat shock proteins (HSPs) are an adaptive response, however long-term, excessive changes are detrimental. Fluorosis activates ERs through IRE1, PERK and ATF6 pathways, increases the expression of HSP60, HSP70 and HSP90, and causes apoptosis and oxidative damage in duodenal tissue. In addition, fluorosis can activate the MAPK signaling pathway. This article can provide a reference for exploring the potential duodenal toxicity of sodium fluoride.
氟是人体必需的微量元素之一。然而，过量的氟对人类和动物健康构成重大威胁。氟中毒可能导致十二指肠的病理损伤，但其潜在机制仍需进一步研究。本研究旨在探讨长期暴露于氟化钠（0、500、1000、2000mg/kg）对鸡十二指肠的影响。结果表明，氟化钠暴露后，肠上皮细胞排列紊乱、坏死甚至脱落，杯状细胞和黏液分泌增加，十二指肠组织诱导出炎症反应。氧化应激、内质网应激（ERs）和热休克蛋白（HSPs）是一种适应性反应，然而长期、过度的变化是有害的。氟中毒通过IRE1、PERK和ATF6途径激活内质网应激，增加HSP60、HSP70和HSP90的表达，并导致十二指肠组织凋亡和氧化损伤。此外，氟中毒可激活丝裂原活化蛋白激酶（MAPK）信号通路。本文可为探索氟化钠潜在的十二指肠毒性提供参考。
