Zhang Weiyan, Wang Qingfeng, Liu Hui, Hong Fei, Tang Qingying, Hu Caiyu, Xu Ting, Lu Hongyi, Ye Lei, Zhu Yuanyuan, Song Lei
Department of Pediatrics, The Second Affiliated Hospital of Nantong University, Nantong First People's Hospital, China; Children's Hospital of Soochow University, Jiangsu, China.
Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, China.
Nutr Metab Cardiovasc Dis. 2025 Feb;35(2):103727. doi: 10.1016/j.numecd.2024.08.020. Epub 2024 Sep 4.
The recent emphasis on systemic inflammation markers has focused primarily on their association with cardiac disorders, particularly the prevalence of hypertension, in adults but not children and adolescents. This research aimed to explore the associations between systemic inflammation markers and the occurrence of hypertension in 8- to 17-year-old children and adolescents in the United States.
Data from 6095 participants under 18 years of age were obtained from the National Health and Nutritional Examination Survey (NHANES: 1999-2020). This study examined the associations between the incidence of hypertension and four indicators of systemic inflammation: the systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR). Multivariate logistic regression analysis results are represented as odds ratios (ORs) and 95 % confidence intervals (CIs), and subgroup analyses were conducted to further explore associations. After fully adjusting for potential confounding covariates, the SII, NLR, and PLR were positively associated with hypertension. Compared with individuals in the bottom quartiles, those in the top SII, NLR, and PLR quartiles were 2.12, 2.11, and 1.57 times more likely to have hypertension, respectively. Conversely, the LMR was negatively associated with hypertension incidence, particularly among those in the highest LMR quartiles (OR = 0.59, 95 % CI = 0.39-0.88; P = 0.009). Subgroup analyses revealed that the four indicators exhibited strong correlations with hypertension in male subjects.
This study revealed significant relationships between systemic inflammatory markers and hypertension incidence, highlighting the potential of these markers as hypertension risk indicators, particularly among male patients.
近期对全身炎症标志物的关注主要集中在其与成人心脏疾病的关联上，尤其是高血压的患病率，而对于儿童和青少年的相关研究较少。本研究旨在探讨美国8至17岁儿童和青少年全身炎症标志物与高血压发生之间的关联。
从国家健康与营养检查调查（NHANES：1999 - 2020）中获取了6095名18岁以下参与者的数据。本研究考察了高血压发病率与全身炎症的四个指标之间的关联：全身免疫炎症指数（SII）、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）以及淋巴细胞与单核细胞比值（LMR）。多因素逻辑回归分析结果以优势比（OR）和95%置信区间（CI）表示，并进行亚组分析以进一步探讨关联。在对潜在混杂协变量进行充分调整后，SII、NLR和PLR与高血压呈正相关。与处于四分位数下限的个体相比，处于SII、NLR和PLR四分位数上限的个体患高血压的可能性分别高2.12倍、2.11倍和1.57倍。相反，LMR与高血压发病率呈负相关，尤其是在LMR四分位数最高的人群中（OR = 0.59，95% CI = 0.39 - 0.88；P = 0.009）。亚组分析显示，这四个指标在男性受试者中与高血压有很强的相关性。
本研究揭示了全身炎症标志物与高血压发病率之间的显著关系，突出了这些标志物作为高血压风险指标的潜力，尤其是在男性患者中。
