卟啉对红细胞尿卟啉原脱羧酶的光动力失活作用
Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins.
作者信息
Batlle A M, de Salamanca R E, Chinarro S, Afonso S G, Stella A M
出版信息
Int J Biochem. 1986;18(2):143-7. doi: 10.1016/0020-711x(86)90146-1.
The effects of light and porphyrins on the activity of red cell uroporphyrinogen decarboxylase were studied. Photoinactivation of uroporphyrinogen decarboxylase was dependent on uroporphyrin concentration, irradiation time and temperature. Using 40 W/m2 of UV light intensity, 40-45% decreased activity was produced with 200 microM uroporphyrin I, at 37 degrees C and after 2 hr of illumination. It has been demonstrated that porphyrins photoinactivate uroporphyrinogen decarboxylase and a mechanism for this action in relation to skin lesions is proposed.
研究了光和卟啉对红细胞尿卟啉原脱羧酶活性的影响。尿卟啉原脱羧酶的光失活取决于尿卟啉浓度、照射时间和温度。在37摄氏度下，使用40W/m2的紫外光强度，200微摩尔尿卟啉I在光照2小时后，活性降低了40 - 45%。已经证明卟啉可使尿卟啉原脱羧酶光失活，并提出了这种作用与皮肤病变相关的机制。
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