Cuadrado Coralía Fabiola, Lagos Karina J, Stringasci Mirian Denise, Bagnato Vanderlei Salvador, Romero María Paulina
New Materials Laboratory, Department of Materials, National Polytechnic School, Quito, Ecuador.
São Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil.
Photodiagnosis Photodyn Ther. 2024 Dec;50:104387. doi: 10.1016/j.pdpdt.2024.104387. Epub 2024 Oct 26.
Photodynamic therapy (PDT) and photothermal therapy (PTT) have demonstrated great potential to diagnose and combat localized cancers. As a matter of fact, these techniques are less invasive and have fewer side effects than traditional cancer treatments like surgery, chemotherapy or radiotherapy. This review summarizes the clinical progress in the theranostics (diagnosis and treatment) of various types of regional cancers using these two light stimuli techniques, PDT and PTT. Therefore, clinical advances in cancer diagnosis based on PDT are detailed, including fluorescence-guided PDT for intraoperative cancer detection, optical coherence tomography (OCT)-guided PDT for early cancer detection, and imaging by magnetic resonance imaging (MRI) or computed tomography (CT) assisted through PDT/PTT. Moreover, clinical studies of breast, prostate, skin, gynecologic, head, neck and other varieties of cancer have been addressed to compare the main conditions of these treatments. This work also discussed the principal advantages and drawbacks of PDT and PTT in tumor targeting and cancer therapy. Finally, the usage of nanoparticles as photosensitizers (PSs) and photothermal agents (PAs) have been analyzed. In this manner, the authors have compiled relevant updated studies so that researchers interested in these areas can access it speedily.
光动力疗法（PDT）和光热疗法（PTT）已显示出在诊断和对抗局部癌症方面的巨大潜力。事实上，与手术、化疗或放疗等传统癌症治疗方法相比，这些技术侵入性更小，副作用更少。本综述总结了使用光动力疗法（PDT）和光热疗法（PTT）这两种光刺激技术在各种类型局部癌症的诊疗（诊断和治疗）方面的临床进展。因此，详细介绍了基于PDT的癌症诊断的临床进展，包括用于术中癌症检测的荧光引导PDT、用于早期癌症检测的光学相干断层扫描（OCT）引导PDT，以及通过PDT/PTT辅助的磁共振成像（MRI）或计算机断层扫描（CT）成像。此外，还探讨了乳腺癌、前列腺癌、皮肤癌、妇科癌、头颈癌和其他各类癌症的临床研究，以比较这些治疗的主要情况。这项工作还讨论了PDT和PTT在肿瘤靶向和癌症治疗中的主要优点和缺点。最后，分析了纳米颗粒作为光敏剂（PSs）和光热剂（PAs）的用途。通过这种方式，作者汇编了相关的最新研究，以便对这些领域感兴趣的研究人员能够快速获取。
