关于 Cephalothrix mokievskii（古纽形动物门，纽形动物）中的河豚毒素的首批数据以及有毒纽形动物可能参与海洋生物资源中毒化的情况。

First data on tetrodotoxins in Cephalothrix mokievskii (palaeonemertea, nemertea) and possible involvement OF POISONOUS nemerteans in toxification of marine bioresources.

机构信息

A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, 690041, Vladivostok, Russian Federation.

出版信息

Toxicon. 2024 Nov 28;251:108155. doi: 10.1016/j.toxicon.2024.108155. Epub 2024 Oct 26.

DOI:10.1016/j.toxicon.2024.108155

PMID:39490817

Abstract

We for the first time have recorded the presence of TTX and 11 of its analogues (TTXs) and determined the profile of these toxins by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) in Cephalothrix mokievskii, collected off the coast of Sakhalin Island and also revealed differences in the TTXs profile between C. mokievskii and sibling Cephalothrix cf, simula. We discuss the features of the TTXs profile in C. mokievskii, geographical distribution of TTX-containing nemerteans and its possible implication for toxification of marine bioresources.

摘要

我们首次记录了 TTX 及其 11 种类似物（TTXs）在 Cephalothrix mokievskii 中的存在，并通过高效液相色谱-串联质谱（HPLC-MS/MS）法确定了这些毒素的特征，这些 Cephalothrix mokievskii 是在萨哈林岛沿海采集的，同时还揭示了 C. mokievskii 和其近亲 Cephalothrix cf, simula 之间 TTXs 图谱的差异。我们讨论了 C. mokievskii 中 TTXs 图谱的特征、含 TTX 纽形动物的地理分布及其对海洋生物资源中毒化的可能影响。