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在整个发育过程中及超过两年的时间里用氯化锰长期处理的大鼠纹状体膜中[3H]司哌罗宁和[3H]苄基喹宁环酯结合情况。

[3H]spiperone and [3H]quinuclidinyl benzilate binding in striatal membranes from rats chronically treated with manganese chloride throughout development and for over two years.

作者信息

Leung T K, Lai J C, Lim L

出版信息

Gen Pharmacol. 1986;17(1):121-3. doi: 10.1016/0306-3623(86)90024-8.

DOI:10.1016/0306-3623(86)90024-8
PMID:3949146
Abstract

Chronic treatment of rats with manganese (1 mg MnCl2 X 4H2O per ml of drinking water) from conception till adulthood only slightly decreased [3H]spiperone binding in striatal membranes whereas [3H]quinuclidinyl benzilate binding was not affected. The age-related decreases in dopaminergic and muscarinic cholinergic receptor binding in striatal membranes were not affected by the life-span manganese treatment.

摘要

从受孕到成年期用锰（每毫升饮用水含1毫克氯化锰·4水合物）对大鼠进行长期治疗，仅使纹状体膜中[3H]司哌罗宁结合略有下降，而[3H]喹核醇基苯甲酸酯结合未受影响。纹状体膜中多巴胺能和毒蕈碱型胆碱能受体结合随年龄的下降不受终生锰治疗的影响。

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