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肛周克罗恩病:仍有许多问题没有答案。

Perianal Crohn's disease: Still more questions than answers.

机构信息

Department of Medicine, University of Otago, Christchurch 8011, Canterbury, New Zealand.

Department of Gastroenterology, Alfred Health, Melbourne 3004, Victoria, Australia.

出版信息

World J Gastroenterol. 2024 Oct 21;30(39):4260-4266. doi: 10.3748/wjg.v30.i39.4260.

DOI:10.3748/wjg.v30.i39.4260
PMID:39492828
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11525859/
Abstract

In this editorial we comment on the article by Pacheco published in a recent issue of the . We focus specifically on the burden of illness associated with perianal fistulizing Crohn's disease (PFCD) and the diagnostic and therapeutic challenges in the management of this condition. Evolving evidence has shifted the diagnostic framework for PFCD from anatomical classification systems, to one that is more nuanced and patient-focused to drive ongoing decision making. This editorial aims to reflect on these aspects to help clinicians face the challenge of PFCD in day-to-day clinical practice.

摘要

在这篇社论中,我们对 Pacheco 发表在最近一期 上的文章进行了评论。我们特别关注肛周瘘管性克罗恩病(PFCD)的疾病负担以及这种疾病管理中的诊断和治疗挑战。不断发展的证据已经将 PFCD 的诊断框架从解剖分类系统转变为更细致入微、以患者为中心的系统,以推动持续的决策制定。这篇社论旨在反思这些方面,帮助临床医生应对日常临床实践中 PFCD 的挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b7a/11525859/78063f238ea1/WJG-30-4260-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b7a/11525859/78063f238ea1/WJG-30-4260-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b7a/11525859/78063f238ea1/WJG-30-4260-g001.jpg

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本文引用的文献

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Perianal Fistulizing Crohn's Disease: Utilizing the TOpClass Classification in Clinical Practice to Provide Targeted Individualized Care.肛周瘘管性克罗恩病:在临床实践中运用TOPClass分类法提供针对性的个体化护理
Clin Gastroenterol Hepatol. 2025 May;23(6):914-926. doi: 10.1016/j.cgh.2024.06.047. Epub 2024 Aug 10.
2
Observational Burden of Illness Study in Patients With Crohn's Disease With and Without Perianal Fistulas in the United States.美国克罗恩病伴和不伴肛周瘘患者的疾病负担观察性研究
Gastro Hep Adv. 2023 Aug 24;2(8):1066-1076. doi: 10.1016/j.gastha.2023.08.011. eCollection 2023.
3
Perianal disease in inflammatory bowel disease: Broadening treatment and surveillance strategies for anal cancer.
炎症性肠病的肛周疾病:拓宽肛门癌的治疗和监测策略。
World J Gastroenterol. 2024 Jul 28;30(28):3373-3385. doi: 10.3748/wjg.v30.i28.3373.
4
Perianal Fistulizing Crohn's Disease-Associated Anorectal and Fistula Cancers: Systematic Review and Expert Consensus.肛周瘘管性克罗恩病相关的肛管直肠癌和肛瘘癌:系统评价与专家共识
Clin Gastroenterol Hepatol. 2025 May;23(6):927-945.e2. doi: 10.1016/j.cgh.2024.05.029. Epub 2024 Jun 12.
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The Disease Severity Index for Inflammatory Bowel Disease Is a Valid Instrument that Predicts Complicated Disease.炎症性肠病疾病严重程度指数是一种有效的预测复杂疾病的工具。
Inflamm Bowel Dis. 2024 Nov 4;30(11):2064-2075. doi: 10.1093/ibd/izad294.
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Aliment Pharmacol Ther. 2024 Mar;59(5):656-665. doi: 10.1111/apt.17836. Epub 2023 Dec 19.
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J Clin Med. 2023 Oct 6;12(19):6379. doi: 10.3390/jcm12196379.
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