Krimly Abdullah, Sharaf Raed M
Faculty of Medicine, King Abdulaziz University, Jeddah, SAU.
Cureus. 2024 Oct 2;16(10):e70736. doi: 10.7759/cureus.70736. eCollection 2024 Oct.
This systematic review and meta-analysis aimed to assess the mortality rates of staged bilateral total knee arthroplasty (staBTKA) procedures. This systematic review followed the suggestions and recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020. We performed a primary search in the PubMed, EBSCO, Scopus, Web of Science via Clarivate, and Google Scholar databases. A quantitative data synthesis was conducted to estimate the pooled prevalence of mortality among patients who underwent staBTKA using the MedCalc® Statistical Software version 20.115 (MedCalc Software Ltd., Ostend, Belgium). The Newcastle-Ottawa Scale was used for the quality assessment. The study included 29 studies with data from 115,348 patients. The mortality rate was estimated to be 0.34% (95% confidence interval: 0.18% to 0.55%). The data showed significant interstudy heterogeneity (I = 93.3%). We used funnel plot inspection to visually assess significant publication bias, which showed a symmetrical distribution of the plotted data. Our study found that the mortality rates following staBTKA are relatively high. However, the reliability of our findings is limited due to significant heterogeneity. We recommend that further studies be conducted to provide higher-quality evidence to assess mortality in staBTKA and its trends.
本系统评价和荟萃分析旨在评估分期双侧全膝关节置换术（staBTKA）的死亡率。本系统评价遵循了《系统评价和荟萃分析优先报告项目》（PRISMA）2020的建议。我们在PubMed、EBSCO、Scopus、科睿唯安旗下的Web of Science以及谷歌学术数据库中进行了初步检索。使用MedCalc®统计软件20.115版（MedCalc Software Ltd.，比利时奥斯坦德）进行定量数据合成，以估计接受staBTKA患者的合并死亡率。采用纽卡斯尔-渥太华量表进行质量评估。该研究纳入了29项研究，涉及115348例患者的数据。死亡率估计为0.34%（95%置信区间：0.18%至0.55%）。数据显示研究间存在显著异质性（I² = 93.3%）。我们使用漏斗图检验直观评估显著的发表偏倚，结果显示绘制的数据呈对称分布。我们的研究发现，staBTKA后的死亡率相对较高。然而，由于显著的异质性，我们研究结果的可靠性有限。我们建议开展进一步研究，以提供更高质量的证据来评估staBTKA的死亡率及其趋势。
