Zhu Li, Liu Yi, Yu Fang, Yin Xue Jiao, Yao Qiu Mei, Meng Hai Tao, You Liang Shun, Tong Hong Yan
Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang, China.
Zhejiang Provincial Clinical Research Center for Hematological Disorders, Hangzhou 310003, Zhejiang, China.
J Hematol. 2024 Oct;13(5):245-249. doi: 10.14740/jh1313. Epub 2024 Oct 21.
Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder characterized by enlarged lymph nodes and systemic inflammation, often involving multiple organ dysfunction. However, cutaneous involvement in iMCD is rare and heterogeneous, and studies on the treatment of iMCD with skin involvement are scarce. Here, we present a rare case of iMCD with prominent facial skin involvement, which showed significant improvement with rituximab-based regimen treatment.
特发性多中心Castleman病（iMCD）是一种罕见的淋巴增殖性疾病，其特征为淋巴结肿大和全身炎症，常累及多器官功能障碍。然而，iMCD累及皮肤的情况罕见且表现各异，关于伴有皮肤受累的iMCD治疗的研究也很少。在此，我们报告1例以面部皮肤显著受累为特征的罕见iMCD病例，该病例采用基于利妥昔单抗的方案治疗后有显著改善。
