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女性溯河洄游性鱼类血清蛋白质组的年龄特异性变化：不同发育阶段的比较分析。

Age-specific changes in the serum proteome of female anadromous, hilsa a comparative analysis across developmental stages.

机构信息

Center for NMCG (National Mission for Clean Ganga), Indian Council of Agricultural Research (ICAR)-Central Inland Fisheries Research Institute, Barrackpore, West Bengal, India.

Department of Fisheries Science, Vidyasagar University, Midnapore, West Bengal, India.

出版信息

Front Immunol. 2024 Oct 18;15:1448627. doi: 10.3389/fimmu.2024.1448627. eCollection 2024.

DOI:10.3389/fimmu.2024.1448627
PMID:39493766
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11527666/
Abstract

INTRODUCTION

The proteome profile of the female (Hamilton, 1822), a species of great ecological and economic importance, across various age groups was investigated to comprehend the functional dynamics of the serum proteome for conservation and aquaculture, as well as sustain the population.

METHODS

Advanced liquid chromatography-tandem mass spectrometry LC-MS/MS-based proteomic data were analysed and submitted to the ProteomeXchange Consortium via PRIDE (PRoteomics IDEntifications database). Bioinformatics analysis of serum proteome have been done and it showed different proteins associated with GO Gene Ontology () terms, and the genes associated with enriched KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways (such as phagosome, mTOR, Apelin signalling pathways, herpes simplex virus) implicated in immune responses.

RESULTS

The expression levels of important immunological proteins, such as those involved in cellular defence and inflammatory responses, were significantly different age-dependently. In this study, we annotated 952, 494, 415, and 282 proteins in year classes IV, III, II, and I Hilsa, respectively, and analysed their Protein-Protein Interaction (PPI) networks based on their functional characteristics. From year classes I to IV, new proteins appeared and were more than three-fold. Notably, class I hilsa displayed a lower abundance of proteins than class IV hilsa.

DISCUSSION

This is the first study, to the best of our knowledge, to report the analysis of the serum proteome of hilsa at different developmental stages, and the results can help improve the understanding of the mechanisms underlying the different changes in protein enrichment during migration in hilsa. This analysis also offers crucial insights into the immune system for hilsa conservation and management.

摘要

简介

本研究旨在调查不同年龄组雌性 （Hamilton，1822）的蛋白质组图谱，以了解血清蛋白质组的功能动态，从而为保护和水产养殖以及维持种群提供支持。

方法

采用基于高级液相色谱-串联质谱 LC-MS/MS 的蛋白质组学数据进行分析，并通过 PRIDE（PRoteomics IDEntifications database）向 ProteomeXchange 联盟提交。对血清蛋白质组进行了生物信息学分析，结果表明，不同的蛋白质与 GO 基因本体论（GO Gene Ontology）术语相关，与富集的 KEGG（京都基因与基因组百科全书）途径相关的基因（如吞噬体、mTOR、Apelin 信号通路、单纯疱疹病毒）与免疫反应有关。

结果

重要免疫蛋白的表达水平随年龄的增长而显著不同，如参与细胞防御和炎症反应的蛋白。在这项研究中，我们分别注释了 IV、III、II 和 I 龄级的 952、494、415 和 282 种蛋白质，并根据其功能特征分析了它们的蛋白质-蛋白质相互作用（PPI）网络。从 I 龄级到 IV 龄级，新的蛋白质不断出现，数量增加了三倍以上。值得注意的是，I 龄级的鲥鱼表现出的蛋白质丰度低于 IV 龄级。

讨论

据我们所知，这是首次报道不同发育阶段鲥血清蛋白质组的分析，该结果有助于提高对鲥在洄游过程中不同蛋白富集变化机制的理解。该分析还为鲥的保护和管理提供了有关免疫系统的重要见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/051f/11527666/e20af8f23951/fimmu-15-1448627-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/051f/11527666/1a71b5e270d2/fimmu-15-1448627-g001.jpg
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The ProteomeXchange consortium at 10 years: 2023 update.蛋白质组交换联盟成立十周年：2023 年更新。
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The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences.PRIDE 数据库资源在 2022 年：一个基于质谱的蛋白质组学证据的中心。
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