Department of Ophthalmology, The First Hospital of Jilin University, Changchun, Jilin, China.
PeerJ. 2024 Oct 31;12:e18258. doi: 10.7717/peerj.18258. eCollection 2024.
BACKGROUND & AIMS: To study the change of the lipid layer thickness analysis in medical staff (MS) before and after work, and to explore the significance of measuring lipid layer thickness (LLT) respectively in four quadrants.
Ocular Surface Disease Index (OSDI) questionnaire and video display terminal using time for 55 MS were collected (the informed consent was obtained from all patients). Noninvasive tear break-up time, LLT, tear meniscus height (TMH), meibomian glands (MG) dropout, and blink pattern before and after work (worked for more than 4 h) of 110 eyes were measured by Gaush iDea Ocular surface analyzer. Lid margin abnormalities were evaluated by the slit-lamp microscopy.
The average OSDI score of 55 MS was 25.68 ± 14.91. The average LLT of 110 eyes after work (65.12 ± 3.63 nm) was significantly reduced compared to before work (66.54 ± 4.16 nm), < 0.05. The LLT in the superior quadrant was significantly thinner than that in the other three quadrants, < 0.01. The average LLT was positively correlated with the LLT in the inferior (r = 0.822, < 0.001), nasal (r = 0.261, < 0.001), and temporal quadrant (r = 0.372, < 0.001), while was negatively correlated with the MG dropout in lower lid (r = -0.209, = 0.002). There was a significant correlation between the LLT in the inferior quadrant and the VDTt (r = -0.173, = 0.01). The LLT of inferior quadrant were positively related to the TMH (r = 0.149, = 0.027) and negatively related to MG dropout in lower lid (r = -0.162, = 0.017).
The LLT significantly decreases after work in MS. The distribution of the lipid layer on the ocular surface is uneven. It is unreasonable for current detection instruments to measure the inferior quadrant LLT alone to represent average LLT.
研究医护人员（MS）工作前后的脂质层厚度分析变化，并分别探讨测量四个象限脂质层厚度（LLT）的意义。
对 55 例 MS 患者的眼表面疾病指数（OSDI）问卷和视频显示终端使用时间进行了收集（所有患者均获得知情同意）。使用 Gaush iDea 眼表面分析仪测量了 110 只眼在工作前（工作超过 4 小时）和工作后的非侵入性泪膜破裂时间、LLT、泪膜半月板高度（TMH）、睑板腺（MG）缺失和眨眼模式。通过裂隙灯显微镜评估眼睑边缘异常。
55 例 MS 的平均 OSDI 评分为 25.68 ± 14.91。110 只眼工作后的平均 LLT（65.12 ± 3.63nm）明显低于工作前（66.54 ± 4.16nm），<0.05。上象限的 LLT 明显比其他三个象限薄，<0.01。平均 LLT 与下象限的 LLT 呈正相关（r=0.822，<0.001），与鼻侧（r=0.261，<0.001）和颞侧象限（r=0.372，<0.001）的 LLT 呈正相关，而与下睑的 MG 缺失呈负相关（r=-0.209，=0.002）。下象限的 LLT 与 VDTt 之间存在显著相关性（r=-0.173，=0.01）。下象限的 LLT 与 TMH 呈正相关（r=0.149，=0.027），与下睑的 MG 缺失呈负相关（r=-0.162，=0.017）。
MS 工作后 LLT 明显下降。眼表面脂质层的分布不均匀。目前的检测仪器单独测量下象限的 LLT 来代表平均 LLT 是不合理的。
