经验性饮食炎症模式与癌症风险及癌症特异性死亡率之间的关联：前瞻性队列研究的系统评价和荟萃分析

The association between empirical dietary inflammatory pattern and risk of cancer and cancer-specific mortality: a systematic review and meta-analysis of prospective cohort studies.

作者信息

Hosseini Fatemeh S, Nikparast Ali, Etesami Elahe, Javaheri-Tafti Fatemeh, Asghari Golaleh

机构信息

Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Department of Clinical Nutrition & Dietetics, Faculty of Nutrition Science and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Front Nutr. 2024 Oct 18;11:1462931. doi: 10.3389/fnut.2024.1462931. eCollection 2024.

DOI:10.3389/fnut.2024.1462931

PMID:39494310

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11527705/

Abstract

BACKGROUND/AIM: Current evidence indicates a correlation between the inflammatory potential of diet and the risk of cancer and cancer-specific mortality. This study aimed to assess the association between empirical dietary inflammatory pattern (EDIP), which has recently been designed based on the inflammatory potential of the diet, and the risk of cancer and cancer-specific mortality.

METHODS

A systematic literature search was conducted across the PubMed/Medline, Scopus, and Web of Science databases from January 2016 to March 2024. A random effects model was used to calculate the pooled effect size (ES) and 95% confidence intervals (95% CI). Heterogeneity between studies was assessed using the Cochran Q test and the statistic.

RESULTS

From the initial 229 records, 24 prospective cohort studies with 2,683,350 participants and 37,091 cancer incidence cases, as well as 20,819 cancer-specific mortality, were included in our study. Pooled results indicated a significant association between higher adherence to the EDIP and an increased risk of total cancer (ES: 1.10; 95% CI: 1.05-1.15; = 41.1), colorectal cancer (ES: 1.19; 95% CI: 1.11-1.27; = 41.1), and liver cancer (ES: 1.48; 95% CI: 1.14-1.94; = 36.9). However, no significant association between increased adherence to the EDIP and an increased risk of ovarian or endometrial cancer was found. Furthermore, greater adherence to the EDIP was significantly associated with an increased risk of cancer-specific mortality (ES: 1.18; 95% CI: 1.05-1.33; = 45.4).

CONCLUSION

Our results showed that a diet with higher inflammatory properties is associated with an increased risk of cancer and cancer-specific mortality.

SYSTEMATIC REVIEW REGISTRATION

PROSPERO registration no. CRD42024496912.

摘要

背景/目的：目前的证据表明饮食的炎症潜能与癌症风险及癌症特异性死亡率之间存在关联。本研究旨在评估基于饮食炎症潜能最近设计的经验性饮食炎症模式（EDIP）与癌症风险及癌症特异性死亡率之间的关联。

方法

于2016年1月至2024年3月在PubMed/Medline、Scopus和Web of Science数据库中进行了系统的文献检索。采用随机效应模型计算合并效应量（ES）和95%置信区间（95%CI）。使用Cochran Q检验和I²统计量评估研究间的异质性。

结果

在最初的229条记录中，我们的研究纳入了24项前瞻性队列研究，共2,683,350名参与者，37,091例癌症发病病例，以及20,819例癌症特异性死亡病例。合并结果表明，更高程度地遵循EDIP与总癌症风险增加（ES：1.10；95%CI：1.05 - 1.15；I² = 41.1）、结直肠癌风险增加（ES：1.19；95%CI：1.11 - 1.27；I² = 41.1）和肝癌风险增加（ES：1.48；95%CI：1.14 - 1.94；I² = 36.9）之间存在显著关联。然而，未发现更高程度地遵循EDIP与卵巢癌或子宫内膜癌风险增加之间存在显著关联。此外，更高程度地遵循EDIP与癌症特异性死亡率增加显著相关（ES：1.18；95%CI：1.05 - 1.33；I² = 45.4）。