Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Br J Cancer. 2022 Oct;127(6):1097-1105. doi: 10.1038/s41416-022-01901-8. Epub 2022 Jun 27.
Evidence is limited on inflammation-related dietary patterns and mortality in ovarian cancer survivors.
We examined the associations between pre- and post-diagnosis dietary patterns, including change in diet from before to after diagnosis, and mortality among 1003 ovarian cancer survivors in two prospective cohort studies. Dietary pattern scores for empirical dietary inflammatory pattern (EDIP) and Alternative Healthy Eating Index (AHEI) were calculated based on food frequency questionnaires. We used Cox proportional hazard models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for ovarian cancer-specific and all-cause mortality.
Pre-diagnosis EDIP score and AHEI were not associated with mortality. Among non-high grade serous cases, a higher post-diagnosis EDIP score was associated with increased risk of all-cause mortality (HR = 1.95, 95% CI = 1.04-3.67, p-trend = 0.06). Compared to survivors consuming a low EDIP score diet before and after diagnosis, high post-diagnosis EDIP was associated with increased risk of ovarian cancer specific mortality (pre-to-post diagnosis low/high, HR = 1.38, 95% CI = 0.99-1.92; high/high HR = 1.58, 95% CI = 1.09-2.30) and all-cause mortality (low/high HR = 1.44, 95% CI = 1.06-1.95; high/high HR = 1.55, 95% CI = 1.10-2.19).
Consuming a more inflammatory dietary pattern post-diagnosis was associated with increased mortality in ovarian cancer survivors, suggesting limiting the inflammatory potential of diet post-diagnosis could lead to enhanced survivorship.
关于卵巢癌幸存者炎症相关饮食模式与死亡率的证据有限。
我们在两项前瞻性队列研究中，检查了 1003 名卵巢癌幸存者在诊断前和诊断后的饮食模式（包括从诊断前到诊断后的饮食变化）与死亡率之间的关联。根据食物频率问卷计算经验性饮食炎症模式（EDIP）和替代健康饮食指数（AHEI）的饮食模式评分。我们使用 Cox 比例风险模型计算卵巢癌特异性和全因死亡率的危险比（HR）和 95%置信区间（CI）。
诊断前的 EDIP 评分和 AHEI 与死亡率无关。在非高级别浆液性病例中，较高的诊断后 EDIP 评分与全因死亡率增加相关（HR=1.95，95%CI=1.04-3.67，p 趋势=0.06）。与诊断前后均摄入低 EDIP 评分饮食的幸存者相比，诊断后高 EDIP 与卵巢癌特异性死亡率增加相关（诊断前至诊断后低/高，HR=1.38，95%CI=0.99-1.92；高/高 HR=1.58，95%CI=1.09-2.30）和全因死亡率（低/高 HR=1.44，95%CI=1.06-1.95；高/高 HR=1.55，95%CI=1.10-2.19）。
诊断后摄入更具炎症性的饮食模式与卵巢癌幸存者死亡率增加相关，这表明限制诊断后饮食的炎症潜力可能会提高生存率。
