Zoli G, Pasquinelli G, Bonvicini F, Gasbarrini G, Laschi R
Int J Tissue React. 1986;8(1):47-53.
A scanning electron microscopy (SEM) study was performed on the gastric and duodenal mucosa of 14 patients treated with Aspirin or Piroxicam. Six patients with normal mucosal morphology were treated with either 1.5 g/day of Aspirin (3 patients) or 20 mg/day or Piroxicam (3 patients) for one month. In addition, 8 rheumatic patients were treated with a similar dose of Aspirin (4 patients) or Piroxicam (4 patients) for at least 4 months. SEM was used to evaluate the following parameters: mucosal structure, cellular exfoliation and anisocytosis, alteration of the microvilli (blebs). The mucosa showed various aspects of alterations ranging from minimal changes (microvillar alteration) to a completely subverted structure both in the stomach and in the duodenum. Mucosal changes, both on the edge of the macroscopic lesions and at a distance from these, were visible with SEM even when endoscopy was normal. Piroxicam appeared slightly less damaging than Aspirin, and no difference was observed between short-term and long-term treated patients, either with Aspirin or with Piroxicam.
对14例接受阿司匹林或吡罗昔康治疗的患者的胃和十二指肠黏膜进行了扫描电子显微镜（SEM）研究。6例黏膜形态正常的患者，分别接受1.5 g/天的阿司匹林（3例）或20 mg/天的吡罗昔康（3例）治疗1个月。此外，8例风湿患者接受了相似剂量的阿司匹林（4例）或吡罗昔康（4例）治疗至少4个月。SEM用于评估以下参数：黏膜结构、细胞脱落和红细胞大小不均、微绒毛改变（泡状）。黏膜呈现出各种改变，从轻微变化（微绒毛改变）到胃和十二指肠中结构完全被破坏。即使内镜检查正常，在宏观病变边缘及远离这些病变处的黏膜变化在SEM下也可见。吡罗昔康造成的损害似乎略小于阿司匹林，且在接受阿司匹林或吡罗昔康治疗的短期和长期患者之间未观察到差异。
