Trabucchi E, Mukenge S, Baratti C, Colombo R, Fregoni F, Montorsi W
Int J Tissue React. 1986;8(1):79-84.
Mucosal biopsies from patients with Crohn's disease and with ulcerative colitis were studied by scanning electron microscopy. Important abnormalities of the mucosal surface were found in both diseases. For Crohn's disease, the characteristic abnormality was loss of the regularity of the polygonal units, but with preservation of the mucosal integrity and of the normal mucosal design. For ulcerative colitis, the abnormalities were disorganization of the cells, signs of sloughing, and superficial erosions. Patients with Crohn's disease always had a significantly increased number of muciparous cells, while those with ulcerative colitis had obvious signs of decreased mucus production. The lesions of ulcerative colitis could be seen under the scanning electron microscope in mucosal areas that appeared normal endoscopically. We feel therefore that scanning electron microscopy of biopsy specimens from patients with inflammatory bowel diseases can be of great help in differential diagnosis.
通过扫描电子显微镜对克罗恩病和溃疡性结肠炎患者的黏膜活检标本进行了研究。在这两种疾病中均发现了黏膜表面的重要异常情况。对于克罗恩病，其特征性异常为多边形单位的规则性丧失，但黏膜完整性和正常黏膜结构得以保留。对于溃疡性结肠炎，异常表现为细胞排列紊乱、脱落迹象和浅表糜烂。克罗恩病患者的黏液分泌细胞数量总是显著增加，而溃疡性结肠炎患者则有黏液分泌明显减少的迹象。在电子显微镜下可以看到溃疡性结肠炎的病变存在于内镜检查看似正常的黏膜区域。因此，我们认为对炎症性肠病患者活检标本进行扫描电子显微镜检查对鉴别诊断有很大帮助。
