Iqbal Sajid, Chen Xiaoxiao, Sohail Muhammad, Wu Fazong, Fang Shiji, Ma Ji, Wang Haiyong, Zhao Zhongwei, Shu Gaofeng, Chen Minjiang, Du Yong-Zhong, Ji Jiansong
Zhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Lishui Hospital of Zhejiang University, Lishui, 323000, China.
Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Biomater Sci. 2024 Dec 3;12(24):6368-6381. doi: 10.1039/d4bm01120a.
Advances in nanotechnology offer promising strategies to overcome the limitations of single-drug therapies in hepatocellular carcinoma (HCC) and other cancers such as multidrug resistance and variable drug tolerances. This study proposes a targeted nanoparticle system based on a poly(β-aminoester) (PβAE) core and a hyaluronic acid (HA) shell, designed for the codelivery of doxorubicin (DOX) and indocyanine green (ICG) to effectively treat HCC. These nanoparticles demonstrated remarkable physicochemical and colloidal stability, pH- and temperature-responsive release, enhanced cellular uptake, and drug retention within tumors. Upon near-infrared (NIR) irradiation, the photothermal conversion of ICG elevated local tumor temperatures up to 53.6 °C, enhancing apoptotic cell death significantly compared to chemotherapy alone ( < 0.05). Furthermore, the dual delivery system significantly enhanced therapeutic efficacy, as evidenced by a marked decrease in tumor growth compared to controls ( < 0.01). These findings illustrate that the HA/PβAE/DOX/ICG nanoparticles are not only able to precisely target tumor cells but also overcome the limitations associated with traditional chemotherapies and photothermal treatments, suggesting a promising avenue for clinical translation of cancer therapy.
纳米技术的进展为克服肝细胞癌（HCC）及其他癌症中单药治疗的局限性提供了有前景的策略，如多药耐药性和不同的药物耐受性。本研究提出了一种基于聚（β-氨基酯）（PβAE）核和透明质酸（HA）壳的靶向纳米颗粒系统，设计用于共递送阿霉素（DOX）和吲哚菁绿（ICG）以有效治疗HCC。这些纳米颗粒表现出显著的物理化学和胶体稳定性、pH和温度响应释放、增强的细胞摄取以及肿瘤内的药物保留。在近红外（NIR）照射下，ICG的光热转换将局部肿瘤温度升高至53.6°C，与单独化疗相比，显著增强了凋亡性细胞死亡（<0.05）。此外，与对照组相比，双递送系统显著增强了治疗效果，肿瘤生长明显减少（<0.01）证明了这一点。这些发现表明，HA/PβAE/DOX/ICG纳米颗粒不仅能够精确靶向肿瘤细胞，还能克服与传统化疗和光热治疗相关的局限性，为癌症治疗的临床转化提供了一条有前景的途径。
