对格雷戈里等人的评论：对阿片类药物戒断反应的恐惧不应阻碍丁丙诺啡的起始治疗。
Commentary on Gregory et al.: Fear of precipitated opioid withdrawal should not prevent buprenorphine initiation.
作者信息
Springer Sandra A
机构信息
Department of Internal Medicine, Section of Infectious Diseases, AIDS Program, Yale School of Medicine, New Haven, CT, USA.
出版信息
Addiction. 2025 Jan;120(1):21-22. doi: 10.1111/add.16701. Epub 2024 Nov 4.
Abstract
Provision of buprenorphine treatment for opioid use disorder is often stymied by clinicians’ concerns for precipitated opioid withdrawal. Gregory et al’s systematic review identified a low level of precipitated withdrawal with buprenorphine induction even among persons who reported fentanyl use. Evidence, not fear should guide treatment.
摘要
为阿片类药物使用障碍提供丁丙诺啡治疗常常因临床医生对阿片类药物戒断反应的担忧而受阻。格雷戈里等人的系统评价发现，即使在报告使用过芬太尼的人群中，丁丙诺啡诱导引发的戒断反应程度也较低。应该依据证据而非恐惧来指导治疗。
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本文引用的文献
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Extended-Release 7-Day Injectable Buprenorphine for Patients With Minimal to Mild Opioid Withdrawal.经改良的 7 天缓释注射用丁丙诺啡治疗轻至中度阿片类药物戒断症状。
JAMA Netw Open. 2024 Jul 1;7(7):e2420702. doi: 10.1001/jamanetworkopen.2024.20702.
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Am J Addict. 2024 Jan;33(1):8-14. doi: 10.1111/ajad.13484. Epub 2023 Nov 8.
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ASAM Clinical Considerations: Buprenorphine Treatment of Opioid Use Disorder for Individuals Using High-potency Synthetic Opioids.ASAM 临床注意事项：使用高纯度合成阿片类药物的个体的丁丙诺啡治疗阿片类药物使用障碍。
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