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高强度聚焦超声在子宫腺肌病治疗中的应用:安全性、疗效和生殖前景的见解。

High-intensity focused ultrasound in adenomyosis treatment: Insights on safety, efficacy, and reproductive prospects.

机构信息

Obstetrics and Gynecology, Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates.

Obs&gyne and uro-gynecologist Dubai Health Latifa hospital, Dubai, United Arab Emirates Consultant Obs&gyne and uro-gynecologist Dubai Health-Latifa hospital Chairperson of scientific committee of Obs&gyne Emirati board In NIHS-UAE University.

出版信息

Womens Health (Lond). 2024 Jan-Dec;20:17455057241295593. doi: 10.1177/17455057241295593.

DOI:10.1177/17455057241295593
PMID:39494764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11536486/
Abstract

The management of adenomyosis has undergone significant evolution, moving from traditional surgical interventions like hysterectomy to more conservative methods aimed at preserving fertility. Essential roles have been played by uterine-sparing surgeries and uterine artery embolization. Despite these advancements, there is a growing interest in less invasive alternatives. This review delves into the potential of high-intensity focused ultrasound (HIFU). HIFU employs focused ultrasound waves for precise ablation of adenomyotic lesions. The review conducts a thorough analysis of HIFU principles, safety, efficacy, and its possible synergies with other therapies. HIFU seems to be effective for adenomyosis treatment, demonstrating a favorable adverse effect profile and suitability for fertility preservation. Combining HIFU with hormonal treatment appears to enhance long-term symptom control, presenting a promising and comprehensive approach for managing adenomyosis. The goal of this article is to develop a comprehensive understanding of HIFU's role in contemporary adenomyosis management and to explore areas requiring further research.

摘要

子宫腺肌病的管理已经发生了重大演变,从传统的手术干预(如子宫切除术)转向更保守的方法,旨在保留生育能力。子宫保留手术和子宫动脉栓塞术发挥了重要作用。尽管取得了这些进展,但人们对微创替代方法的兴趣日益浓厚。本综述探讨了高强度聚焦超声(HIFU)的潜力。HIFU 采用聚焦超声波对子宫腺肌病病灶进行精确消融。本综述对 HIFU 的原理、安全性、疗效及其与其他疗法的协同作用进行了全面分析。HIFU 似乎对子宫腺肌病的治疗有效,具有良好的不良反应谱,适合于生育力保存。将 HIFU 与激素治疗相结合似乎可以增强长期症状控制,为子宫腺肌病的管理提供了一种有前途且全面的方法。本文的目的是全面了解 HIFU 在当代子宫腺肌病管理中的作用,并探讨需要进一步研究的领域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7263/11536486/0a043f22bfea/10.1177_17455057241295593-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7263/11536486/c0cb41434b07/10.1177_17455057241295593-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7263/11536486/0a043f22bfea/10.1177_17455057241295593-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7263/11536486/c0cb41434b07/10.1177_17455057241295593-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7263/11536486/0a043f22bfea/10.1177_17455057241295593-fig2.jpg

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本文引用的文献

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Pregnancy outcomes of adenomyotic patients with primary infertility after high-intensity focused ultrasound treatment.高强度聚焦超声治疗原发性不孕腺肌病患者的妊娠结局。
Int J Hyperthermia. 2023;40(1):2264547. doi: 10.1080/02656736.2023.2264547. Epub 2023 Oct 30.
2
Comparison of pregnancy outcomes in infertile patients with different types of adenomyosis treated with high-intensity focused ultrasound.高强度聚焦超声治疗不同类型子宫腺肌病不孕患者的妊娠结局比较。
Int J Hyperthermia. 2023;40(1):2238140. doi: 10.1080/02656736.2023.2238140.
3
Effects of high-intensity focused ultrasound combined with levonorgestrel-releasing intrauterine system on patients with adenomyosis.
高强度聚焦超声联合左炔诺孕酮宫内缓释系统治疗子宫腺肌病的效果。
Sci Rep. 2023 Jun 19;13(1):9903. doi: 10.1038/s41598-023-37096-y.
4
Uterine rupture after high-intensity focused ultrasound ablation of adenomyosis: a case report and literature review.高强度聚焦超声消融治疗子宫腺肌病后子宫破裂 1 例报告并文献复习
Int J Hyperthermia. 2023;40(1):2212885. doi: 10.1080/02656736.2023.2212885.
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Factors influencing USgHIFU ablation for adenomyosis with NPVR ≥ 50.影响 USgHIFU 消融治疗 NPVR≥50 的子宫腺肌病的因素。
Int J Hyperthermia. 2023;40(1):2211753. doi: 10.1080/02656736.2023.2211753.
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Comparison of high-intensity focused ultrasound for the treatment of internal and external adenomyosis based on magnetic resonance imaging classification.基于磁共振成像分类的高强度聚焦超声治疗子宫内腺肌病和子宫外腺肌病的比较。
Int J Hyperthermia. 2023;40(1):2211268. doi: 10.1080/02656736.2023.2211268.
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High intensity focused ultrasound treatment for adenomyosis: comparison of efficacy based on MRI features.高强度聚焦超声治疗子宫腺肌病:基于 MRI 特征的疗效比较。
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Comparison of the treatment efficacies of HIFU, HIFU combined with GnRH-a, and HIFU combined with GnRH-a and LNG-IUS for adenomyosis: A systematic review and meta-analysis.高强度聚焦超声(HIFU)、HIFU联合促性腺激素释放激素激动剂(GnRH-a)以及HIFU联合GnRH-a和左炔诺孕酮宫内缓释系统(LNG-IUS)治疗子宫腺肌病的疗效比较:一项系统评价与Meta分析
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