Gab1在心血管疾病中的作用：一个尚未充分探索且存在争议的研究领域。 - Suppr

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Gab1 in Cardiovascular Disease: An Insufficiently Explored and Controversial Research Area.

作者信息

Jing Da-Tan, Li Fei, Ren Li-Ying

机构信息

Department of Cardiology, Weifang Traditional Chinese Hospital, Weifang, 261000, PR China.

出版信息

Cardiovasc Drugs Ther. 2025 Feb;39(1):5-6. doi: 10.1007/s10557-024-07638-1. Epub 2024 Nov 4.

DOI:10.1007/s10557-024-07638-1

PMID:39495378

Abstract

摘要

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Gab1 Overexpression Attenuates Susceptibility to Ventricular Arrhythmias in Pressure Overloaded Heart Failure Mouse Hearts.Gab1 过表达可减轻压力超负荷性心力衰竭小鼠心脏对心律失常的易感性。

Cardiovasc Drugs Ther. 2024 Apr;38(2):253-262. doi: 10.1007/s10557-022-07394-0. Epub 2022 Nov 14.

Gab1 Overexpression Alleviates Doxorubicin-Induced Cardiac Oxidative Stress, Inflammation, and Apoptosis Through PI3K/Akt Signaling Pathway.Gab1过表达通过PI3K/Akt信号通路减轻阿霉素诱导的心脏氧化应激、炎症和细胞凋亡。

J Cardiovasc Pharmacol. 2022 Dec 1;80(6):804-812. doi: 10.1097/FJC.0000000000001333.

Increased expression of GAB1 promotes inflammation and fibrosis in systemic sclerosis.GAB1 表达增加促进系统性硬化症中的炎症和纤维化。

Exp Dermatol. 2019 Nov;28(11):1313-1320. doi: 10.1111/exd.14033.

Elevated expression of Gab1 promotes breast cancer metastasis by dissociating the PAR complex.Gab1 表达水平升高通过解离 PAR 复合物促进乳腺癌转移。

J Exp Clin Cancer Res. 2019 Jan 21;38(1):27. doi: 10.1186/s13046-019-1025-2.

Gab1 Is Modulated by Chronic Hypoxia in Children with Cyanotic Congenital Heart Defect and Its Overexpression Reduces Apoptosis in Rat Neonatal Cardiomyocytes.Gab1在青紫型先天性心脏病患儿中受慢性缺氧调控，其过表达可减少新生大鼠心肌细胞凋亡。

Biomed Res Int. 2015;2015:718492. doi: 10.1155/2015/718492. Epub 2015 May 19.

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