Nerenz D R, Love R R, Leventhal H, Easterling D V
Health Serv Res. 1986 Feb;20(6 Pt 2):961-76.
The purpose of this study was to determine whether elderly patients receiving cancer chemotherapy experience more emotional distress, difficulty with side effects, and disruption in activities than younger patients. A sample of 217 patients receiving initial chemotherapy treatment for breast cancer or lymphoma was interviewed several times over the first 6 months of treatment. Patients ranged in age from 19 to 83. Included in the interviews were questions on presence, duration, and severity of side effects; response of disease to treatment; and 0-10 ratings of emotional distress, difficulty, and life disruption due to chemotherapy. Information on drugs given, doses, and schedules was obtained from medical charts. In general, elderly patients reported no more difficulty with treatment or emotional distress than did younger patients. This general pattern held across disease types, with some exceptions. These results, combined with previously published studies on the physiological effects of chemotherapy in the elderly, indicate that aggressive treatment should not be withheld from older patients simply because of their age.
本研究的目的是确定接受癌症化疗的老年患者是否比年轻患者经历更多的情绪困扰、副作用困扰以及活动中断。对217名首次接受乳腺癌或淋巴瘤化疗的患者在治疗的前6个月内进行了多次访谈。患者年龄在19岁至83岁之间。访谈内容包括副作用的存在、持续时间和严重程度;疾病对治疗的反应;以及化疗引起的情绪困扰、困难程度和生活中断的0至10分评分。从病历中获取了所给药物、剂量和疗程的信息。总体而言,老年患者报告的治疗困难或情绪困扰并不比年轻患者多。这种总体模式在各种疾病类型中都存在,不过也有一些例外。这些结果,再结合先前发表的关于化疗对老年人生理影响的研究,表明不应仅仅因为年龄而不给老年患者进行积极治疗。