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遗传性出血性毛细血管扩张症患者硬膜下血肿的脑膜中动脉栓塞及氨甲环酸治疗:病例说明

Middle meningeal artery embolization and tranexamic acid therapy for subdural hematoma in a patient with hereditary hemorrhagic telangiectasia: illustrative case.

作者信息

Kushmakov Robert, Cazorla-Morales Ilona, Brenner Keith, Araten David, Shapiro Maksim, Raz Eytan, Placantonakis Dimitris G

机构信息

Touro College of Osteopathic Medicine, New York, New York.

Departments ofNeurosurgery and.

出版信息

J Neurosurg Case Lessons. 2024 Nov 4;8(19). doi: 10.3171/CASE24483.

DOI:10.3171/CASE24483
PMID:39496155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11539288/
Abstract

BACKGROUND

Subdural hematoma is a rare manifestation of hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu disease. Here, the authors present a patient with HHT and a large chronic subdural hematoma, for whom nonsurgical management was pursued.

OBSERVATIONS

A 49-year-old right-handed male with a history of hypertension and familial HHT presented with complaints of mild confusion and left hemiparesis over several days. Noncontrast head computed tomography images demonstrated a large chronic right hemisphere subdural hematoma compressing the right cerebral hemisphere and causing a 1.3-cm midline shift. Due to concerns about surgical complications arising from hemorrhages of cryptic telangiectasias, the patient was treated conservatively with middle meningeal artery embolization and adjuvant tranexamic acid. There was clinical and radiological resolution several months later.

LESSONS

This case highlights the rarity of a subdural hematoma as a manifestation of HHT and the nonsurgical treatment strategy as a mechanism to avoid hemorrhagic complications of surgical evacuation. https://thejns.org/doi/10.3171/CASE24483.

摘要

背景

硬膜下血肿是遗传性出血性毛细血管扩张症(HHT)的一种罕见表现,HHT也被称为奥斯勒-韦伯-伦杜病。在此,作者报告一名患有HHT和巨大慢性硬膜下血肿的患者,对其采用了非手术治疗。

观察结果

一名49岁右利手男性,有高血压病史和家族性HHT,数天来出现轻度意识模糊和左侧偏瘫的症状。头颅非增强计算机断层扫描图像显示,一个巨大的慢性右侧半球硬膜下血肿压迫右侧大脑半球,导致中线移位1.3厘米。由于担心隐匿性毛细血管扩张出血引发手术并发症,对该患者采用脑膜中动脉栓塞和辅助氨甲环酸进行保守治疗。数月后患者临床症状和影像学表现均得到缓解。

经验教训

该病例凸显了硬膜下血肿作为HHT表现的罕见性,以及非手术治疗策略作为避免手术清除血肿出血并发症的一种手段。https://thejns.org/doi/10.3171/CASE24483 。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9e5/11539288/11140bfc849f/CASE24483_figure_3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9e5/11539288/f3d885b0dd30/CASE24483_figure_1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9e5/11539288/83934bac72ac/CASE24483_figure_2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9e5/11539288/11140bfc849f/CASE24483_figure_3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9e5/11539288/f3d885b0dd30/CASE24483_figure_1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9e5/11539288/83934bac72ac/CASE24483_figure_2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9e5/11539288/11140bfc849f/CASE24483_figure_3.jpg

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本文引用的文献

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Embolization of middle meningeal artery for chronic subdural hematoma: Do we have sufficient evidence?慢性硬膜下血肿的脑膜中动脉栓塞术:我们有足够的证据吗?
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Middle Meningeal Artery Embolization for Chronic Subdural Hematoma: Predictors of Clinical and Radiographic Failure from 636 Embolizations.中脑膜动脉栓塞治疗慢性硬脑膜下血肿:636 例栓塞治疗的临床和影像学失败的预测因素。
Radiology. 2023 May;307(4):e222045. doi: 10.1148/radiol.222045. Epub 2023 Apr 18.
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大脑中动脉栓塞术治疗慢性硬膜下血肿有效且具有成本效益。
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