单环β-内酰胺抗生素的研究。III. N-（芳族杂环取代）氮杂环丁烷-2-酮的合成与抗菌活性
Studies on monocyclic beta-lactam antibiotics. III. Synthesis and antibacterial activity of N-(aromatic heterocyclic substituted)azetidin-2-ones.
作者信息
Yoshida C, Tanaka K, Nakano J, Todo Y, Yamafuji T, Hattori R, Fukuoka Y, Saikawa I
出版信息
J Antibiot (Tokyo). 1986 Jan;39(1):76-89. doi: 10.7164/antibiotics.39.76.
PMID:3949632
Abstract
The relationship between structure and antibacterial activity among monocyclic beta-lactams having a pyridyl, pyrimidinyl, thiazolyl, imidazolyl, or a tetrazolyl group at N-1 position was investigated. N-(Tetrazol-5-yl)azetidin-2-ones were found to posses excellent activity.
摘要
研究了在N-1位带有吡啶基、嘧啶基、噻唑基、咪唑基或四唑基的单环β-内酰胺类化合物的结构与抗菌活性之间的关系。发现N-（5-四唑基）氮杂环丁烷-2-酮具有优异的活性。
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