Department of Neurosurgery, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Hangzhou, China.
Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, China.
CNS Neurosci Ther. 2024 Nov;30(11):e70105. doi: 10.1111/cns.70105.
Border-associated macrophages (BAMs) play a pivotal role in maintaining brain homeostasis and responding to pathological conditions. Understanding their origins, characteristics, and roles in both healthy and diseased brains is crucial for advancing our knowledge of neuroinflammatory and neurodegenerative diseases. This review addresses the ontogeny, replenishment, microenvironmental regulation, and transcriptomic heterogeneity of BAMs, highlighting recent advancements in lineage tracing and fate-mapping studies. Furthermore, we examine the roles of BAMs in maintaining brain homeostasis, immune surveillance, and responses to injury and neurodegenerative diseases. Further research is crucial to clarify the dynamic interplay between BAMs and the brain's microenvironment in health and disease. This effort will not only resolve existing controversies but also reveal new therapeutic targets for neuroinflammatory and neurodegenerative disorders, pushing the boundaries of neuroscience.
边界相关巨噬细胞（BAMs）在维持大脑内环境稳定和应对病理状态方面发挥着关键作用。了解它们在健康和患病大脑中的起源、特征和作用对于深入了解神经炎症和神经退行性疾病至关重要。本综述探讨了 BAMs 的个体发生、补充、微环境调节和转录组异质性，重点介绍了谱系追踪和命运图谱研究的最新进展。此外，我们还研究了 BAMs 在维持大脑内环境稳定、免疫监视以及对损伤和神经退行性疾病的反应中的作用。进一步的研究对于阐明 BAMs 与大脑微环境在健康和疾病中的动态相互作用至关重要。这一努力不仅将解决现有争议，还将为神经炎症和神经退行性疾病揭示新的治疗靶点，推动神经科学的发展。
