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根皮苷通过调节 TLR2/MyD88/NF-κB 通路减轻蛛网膜下腔出血引起的炎症反应。

Phloretin attenuates inflammation induced by subarachnoid hemorrhage through regulation of the TLR2/MyD88/NF-kB pathway.

机构信息

Department of Neurosurgery, Shanxi Provincial People's Hospital, Shuangtasi Street, 29, Taiyuan, 030012, China.

Comprehensive Examination Department, Children's Hospital of Shanxi, Taiyuan, 030000, China.

出版信息

Sci Rep. 2024 Nov 4;14(1):26583. doi: 10.1038/s41598-024-77671-5.

DOI:10.1038/s41598-024-77671-5
PMID:39496685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11534998/
Abstract

Subarachnoid hemorrhage (SAH), a stroke subtype associated with high mortality, is closely linked to neuroinflammation. Phloretin, a naturally occurring flavonoid abundant in fruits, possesses anti-inflammatory properties. However, its specific role in SAH remains unclear. Therefore, we aimed to investigate the potential role of phloretin in SAH. We established in vitro and in vivo SAH models to assess the effects of phloretin. Subsequently, utilizing SAH-related public datasets from the GEO database, we identified key genes associated with SAH and investigated the potential mechanism of action of phloretin. Our findings reveal that phloretin significantly improves prognostic outcomes and mitigates inflammation in SAH mice. Moreover, our results suggest that phloretin mitigates neuroinflammation by inhibiting the TLR2/MYD88/NF-κB pathway.

摘要

蛛网膜下腔出血（SAH）是一种与高死亡率相关的中风亚型，与神经炎症密切相关。根皮苷是一种存在于水果中的天然类黄酮，具有抗炎作用。然而，其在 SAH 中的具体作用尚不清楚。因此，我们旨在研究根皮苷在 SAH 中的潜在作用。我们建立了体外和体内 SAH 模型来评估根皮苷的作用。随后，利用 GEO 数据库中与 SAH 相关的公共数据集，我们鉴定了与 SAH 相关的关键基因，并研究了根皮苷的潜在作用机制。我们的研究结果表明，根皮苷可显著改善 SAH 小鼠的预后并减轻炎症。此外，我们的结果表明，根皮苷通过抑制 TLR2/MYD88/NF-κB 通路来减轻神经炎症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ed8/11534998/d39ca052d686/41598_2024_77671_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ed8/11534998/bef6e901ea5a/41598_2024_77671_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ed8/11534998/223736fc42fc/41598_2024_77671_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ed8/11534998/4615b183ee63/41598_2024_77671_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ed8/11534998/515370f753f4/41598_2024_77671_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ed8/11534998/ddc1c4db1770/41598_2024_77671_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ed8/11534998/d39ca052d686/41598_2024_77671_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ed8/11534998/bef6e901ea5a/41598_2024_77671_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ed8/11534998/223736fc42fc/41598_2024_77671_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ed8/11534998/4615b183ee63/41598_2024_77671_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ed8/11534998/515370f753f4/41598_2024_77671_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ed8/11534998/ddc1c4db1770/41598_2024_77671_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ed8/11534998/d39ca052d686/41598_2024_77671_Fig6_HTML.jpg

相似文献

[1]
Phloretin attenuates inflammation induced by subarachnoid hemorrhage through regulation of the TLR2/MyD88/NF-kB pathway.

Sci Rep. 2024-11-4

[2]
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[3]
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[4]
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[5]
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[6]
Phloretin as a Potent Natural TLR2/1 Inhibitor Suppresses TLR2-Induced Inflammation.

Nutrients. 2018-7-5

[7]
Propofol alleviates M1 polarization and neuroinflammation of microglia in a subarachnoid hemorrhage model , by targeting the miR-140-5p/TREM-1/NF-κB signaling axis.

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[8]
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J Neuroinflammation. 2020-5-11

[9]
Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-κB Pathway and NLRP3 Inflammasome.

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[10]
Rutin Inhibits Neuroinflammation and Provides Neuroprotection in an Experimental Rat Model of Subarachnoid Hemorrhage, Possibly Through Suppressing the RAGE-NF-κB Inflammatory Signaling Pathway.

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引用本文的文献

[1]
Dexmedetomidine reduces in-hospital mortality in aneurysmal subarachnoid hemorrhage patients by modulating three key genes and inflammatory pathways: insights from clinical and bioinformatics analyses.

Front Neurol. 2025-7-24

[2]
Blood-brain barrier repair: potential and challenges of stem cells and exosomes in stroke treatment.

Front Cell Neurosci. 2025-4-7

本文引用的文献

[1]
The Impact of Microglia on Neurodevelopment and Brain Function in Autism.

Biomedicines. 2024-1-17

[2]
Combining WGCNA and machine learning to construct immune-related EMT patterns to predict HCC prognosis and immune microenvironment.

Aging (Albany NY). 2023-7-21

[3]
The mechanism of ferroptosis in early brain injury after subarachnoid hemorrhage.

Front Immunol. 2023

[4]
LDC7559 inhibits microglial activation and GSDMD-dependent pyroptosis after subarachnoid hemorrhage.

Front Immunol. 2023

[5]
Phloretin decreases microglia-mediated synaptic engulfment to prevent chronic mild stress-induced depression-like behaviors in the mPFC.

Theranostics. 2023

[6]
Inhibition of CCR2 attenuates neuroinflammation and neuronal apoptosis after subarachnoid hemorrhage through the PI3K/Akt pathway.

J Neuroinflammation. 2022-12-25

[7]
Progress in Research on TLR4-Mediated Inflammatory Response Mechanisms in Brain Injury after Subarachnoid Hemorrhage.

Cells. 2022-11-26

[8]
Therapeutic targeting of microglia mediated oxidative stress after neurotrauma.

Front Med (Lausanne). 2022-11-3

[9]
Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis.

J Neuroinflammation. 2022-10-4

[10]
Phloretin inhibits glucose transport and reduces inflammation in human retinal pigment epithelial cells.

Mol Cell Biochem. 2023-1

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