Department of Neurosurgery, Shanxi Provincial People's Hospital, Shuangtasi Street, 29, Taiyuan, 030012, China.
Comprehensive Examination Department, Children's Hospital of Shanxi, Taiyuan, 030000, China.
Sci Rep. 2024 Nov 4;14(1):26583. doi: 10.1038/s41598-024-77671-5.
Subarachnoid hemorrhage (SAH), a stroke subtype associated with high mortality, is closely linked to neuroinflammation. Phloretin, a naturally occurring flavonoid abundant in fruits, possesses anti-inflammatory properties. However, its specific role in SAH remains unclear. Therefore, we aimed to investigate the potential role of phloretin in SAH. We established in vitro and in vivo SAH models to assess the effects of phloretin. Subsequently, utilizing SAH-related public datasets from the GEO database, we identified key genes associated with SAH and investigated the potential mechanism of action of phloretin. Our findings reveal that phloretin significantly improves prognostic outcomes and mitigates inflammation in SAH mice. Moreover, our results suggest that phloretin mitigates neuroinflammation by inhibiting the TLR2/MYD88/NF-κB pathway.
蛛网膜下腔出血（SAH）是一种与高死亡率相关的中风亚型，与神经炎症密切相关。根皮苷是一种存在于水果中的天然类黄酮，具有抗炎作用。然而，其在 SAH 中的具体作用尚不清楚。因此，我们旨在研究根皮苷在 SAH 中的潜在作用。我们建立了体外和体内 SAH 模型来评估根皮苷的作用。随后，利用 GEO 数据库中与 SAH 相关的公共数据集，我们鉴定了与 SAH 相关的关键基因，并研究了根皮苷的潜在作用机制。我们的研究结果表明，根皮苷可显著改善 SAH 小鼠的预后并减轻炎症。此外，我们的结果表明，根皮苷通过抑制 TLR2/MYD88/NF-κB 通路来减轻神经炎症。
