Wang Hongying, Zou Jincheng, Zhao Shiqing, Zhang Aili
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Med Biol Eng Comput. 2025 Mar;63(3):793-806. doi: 10.1007/s11517-024-03230-9. Epub 2024 Nov 4.
Radiofrequency ablation is a widely accepted minimal-invasive and effective local treatment for tumors. However, its current application in esophageal cancer treatment is limited to targeting thin and superficial lesions, such as Barrett's Esophagus. This study proposes an optimization method using multiple electrodes simultaneously to regulate the temperature field and achieve conformal ablation of tumors. A particle swarm optimization algorithm, coupled with a three-dimensional thermal ablation model, was developed to optimize the status of the functioning electrodes, the optimal voltage (V), and treatment duration (t) for targeted esophageal tumors. This approach takes into account both the electrical and thermal interactions of the electrodes. The results indicate that for esophageal cancers at various stages, with thickness (c) ranging from 4.5 mm to 10.0 mm, major axis (a) ranging from 7.3 mm to 27.3 mm, and minor axis (b) equaling 7.3 mm or 27.3 mm, as well as non-symmetrical geometries, complete tumor coverage (over 99.5%) close to conformal can be achieved. This method illustrates possible precise conformal ablation of esophageal cancers and it may also be used for conformal treatments of other intraluminal lesions.
射频消融是一种广泛认可的针对肿瘤的微创且有效的局部治疗方法。然而，其目前在食管癌治疗中的应用仅限于针对诸如巴雷特食管等薄且浅表的病变。本研究提出一种使用多个电极同时调节温度场并实现肿瘤适形消融的优化方法。开发了一种结合三维热消融模型的粒子群优化算法，以优化功能电极的状态、针对目标食管肿瘤的最佳电压（V）和治疗持续时间（t）。该方法同时考虑了电极的电相互作用和热相互作用。结果表明，对于不同阶段的食管癌，厚度（c）在4.5毫米至10.0毫米之间，长轴（a）在7.3毫米至27.3毫米之间，短轴（b）等于7.3毫米或27.3毫米，以及对于非对称几何形状，可实现接近适形的完全肿瘤覆盖（超过99.5%）。该方法说明了食管癌可能实现精确适形消融，并且它也可用于其他腔内病变的适形治疗。
