Beaulieu N, Lovering E G
J Assoc Off Anal Chem. 1986 Jan-Feb;69(1):167-9.
A liquid chromatographic method is described for determination of perphenazine and perphenazine sulfoxide in representative dosage forms. Sulfoxide levels were nondetectable or less than 1% in tablets and in an injectable product. Sulfoxide levels increase with time in some syrup formulations and may be as high as 11% in syrup formulations before their expiration date.
本文描述了一种液相色谱法,用于测定代表性剂型中奋乃静和奋乃静亚砜的含量。在片剂和注射剂产品中,亚砜含量未检出或低于1%。在某些糖浆制剂中,亚砜含量会随时间增加,在糖浆制剂过期前可能高达11%。