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用于测定药物剂型中奋乃静及其亚砜稳定性的液相色谱法。

Liquid chromatographic method for perphenazine and its sulfoxide in pharmaceutical dosage forms for determination of stability.

作者信息

Beaulieu N, Lovering E G

出版信息

J Assoc Off Anal Chem. 1986 Jan-Feb;69(1):167-9.

PMID:3949688
Abstract

A liquid chromatographic method is described for determination of perphenazine and perphenazine sulfoxide in representative dosage forms. Sulfoxide levels were nondetectable or less than 1% in tablets and in an injectable product. Sulfoxide levels increase with time in some syrup formulations and may be as high as 11% in syrup formulations before their expiration date.

摘要

本文描述了一种液相色谱法,用于测定代表性剂型中奋乃静和奋乃静亚砜的含量。在片剂和注射剂产品中,亚砜含量未检出或低于1%。在某些糖浆制剂中,亚砜含量会随时间增加,在糖浆制剂过期前可能高达11%。

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