BACKGROUND: This study aimed to assess the quality and readability of large language model-generated responses to frequently asked questions (FAQs) about Kienböck's disease (KD). METHODS: Nineteen FAQs about KD were selected, and the questions were divided into three categories: general knowledge, diagnosis, and treatment. The questions were inputted into the Chat Generative Pre-trained Transformer 4 (ChatGPT4) webpage using the zero-shot prompting method, and the responses were recorded. Hand surgeons with at least 5 years of experience and advanced English proficiency were individually contacted over instant WhatsApp messaging and requested to assess the responses. The quality of each response was analyzed by 33 experienced hand surgeons using the Global Quality Scale (GQS). The readability was assessed with the Flesch-Kincaid Grade Level (FKGL) and Flesch Reading Ease Score (FRES). RESULTS: The mean GQS score was 4.28 out of a maximum of 5 points. Most raters assessed the quality as good (270 of 627 responses; 43.1%) or excellent (260 of 627 responses; 41.5%). The mean FKGL was 15.5, and the mean FRES was 23.4, both of which are considered above the college graduate level. No statistically significant differences were found in the quality and readability of responses provided for questions related to general knowledge, diagnosis, and treatment. CONCLUSIONS: ChatGPT-4 provided high-quality responses to FAQs about KD. However, the primary drawback was the poor readability of these responses. By improving the readability of ChatGPT's output, we can transform it into a valuable information resource for individuals with KD. LEVEL OF EVIDENCE: Level IV, Observational study.