Dinapoli Loredana, Caliandro Morena, Chiesa Silvia, Marconi Elisa, Capocchiano Nikola Dino, Mazzarella Ciro, Bartoli Francesco Beghella, Bracci Serena, Balducci Mario, Chieffo Daniela Pia Rosaria, Fiorentino Alba, Valentini Vincenzo, Tagliaferri Luca, Gambacorta Maria Antonietta, Dinapoli Nicola
UOS di Psicologia Clinica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Dipartimento di Radioterapia Oncologica, Ente Ecclesiastico Ospedale Generale Regionale F. Miulli, Acquaviva delle Fonti(BA), Italy.
Palliat Support Care. 2024 Nov 5;23:e10. doi: 10.1017/S1478951524001111.
The primary aims of this multicenter, prospective observational study were to investigate spiritual well-being, resilience, and psychosocial distress in an Italian sample of glioblastoma patients undergoing radiochemotherapy. The secondary aim was to explore the influence of demographic, clinical, and psychological characteristics on survival.
The assessment was conducted only once, within the first week of radiochemotherapy treatment. Spiritual well-being was evaluated by the Functional Assessment of Chronic Illness Therapy-Spiritual Well-being (FACIT-Sp-12), and religious/spiritual beliefs and practices were evaluated by the System of Belief Inventory. Resilience was evaluated by the Connor-Davidson Resilience Scale (CD-RISC). Psychosocial distress was evaluated the by Distress Thermometer and Hospital Anxiety Depression Scale. We conducted an univariable analysis of overall survival (OS) using data from the most recent follow-up available, considering demographic and clinical variables that could influence survival. Follow-up was defined as either the time of death or the latest follow-up visit recorded.
We recruited 104 patients, and the median follow-up time was 18.3 months. "Distressed" patients had lower scores than "not distressed" patients on the FACIT-Sp-12 and CD-RISC. While OS was not significant according to the FACIT-Sp-12 threshold, the Kaplan-Meier log-rank test was 0.05 according to the CD-RISC threshold. Among demographic variables, age showed significant associations with OS ( = 0.011). Resilience showed significant associations with OS ( = 0.025).
Data showed that high spiritual well-being was associated with high resilience and an absence of psychosocial distress in our sample of glioblastoma patients undergoing radiochemotherapy. Patients with greater resilience survived longer than those with lesser resilience. Profiling spiritual well-being and resilience in glioblastoma patients undergoing radiochemotherapy can be seen as a resource to identify novel characteristics to improve clinical take-in-charge of glioblastoma patients.
这项多中心前瞻性观察性研究的主要目的是调查接受放化疗的意大利胶质母细胞瘤患者样本中的精神幸福感、心理韧性和心理社会困扰。次要目的是探讨人口统计学、临床和心理特征对生存的影响。
评估仅在放化疗治疗的第一周内进行一次。精神幸福感通过慢性病治疗功能评估-精神幸福感（FACIT-Sp-12）进行评估，宗教/精神信仰和实践通过信仰量表系统进行评估。心理韧性通过康纳-戴维森心理韧性量表（CD-RISC）进行评估。心理社会困扰通过痛苦温度计和医院焦虑抑郁量表进行评估。我们使用来自最近一次可用随访的数据对总生存期（OS）进行单变量分析，考虑可能影响生存的人口统计学和临床变量。随访定义为死亡时间或记录的最新随访就诊时间。
我们招募了104名患者，中位随访时间为18.3个月。在FACIT-Sp-12和CD-RISC上，“痛苦”患者的得分低于“不痛苦”患者。虽然根据FACIT-Sp-12阈值OS无显著差异，但根据CD-RISC阈值，卡普兰-迈耶对数秩检验为0.05。在人口统计学变量中，年龄与OS显示出显著关联（=0.011）。心理韧性与OS显示出显著关联（=0.025）。
数据表明，在我们接受放化疗的胶质母细胞瘤患者样本中，高精神幸福感与高心理韧性和无心理社会困扰相关。心理韧性较强的患者比心理韧性较弱的患者存活时间更长。对接受放化疗的胶质母细胞瘤患者的精神幸福感和心理韧性进行剖析可被视为一种资源，以识别新的特征，从而改善胶质母细胞瘤患者的临床管理。
