Bouheraoua Selma, Deghmane Ala-Eddine, Laliam Rym, Guettou Badia, Djedjig Fatiha, Djemaa Meriem, Sellami Youcef, Yousfi Mohamed, Aissat FZohra, Achour Nassima, Mahrane Sadjia, Taha Muhamed-Kheir, Tali Maamar Hassiba
Institut Pasteur d'Algérie, Chéraga, Algeria.
Faculty of pharmacy - University of Algiers 1, Algiers, Algeria.
IJID Reg. 2024 Sep 21;13:100458. doi: 10.1016/j.ijregi.2024.100458. eCollection 2024 Dec.
To monitor the spread of invasive meningococcal disease due to group C of the clonal complex 10217 isolates beyond the sub-Saharan African meningitis belt.
Cases were confirmed by real-time polymerase chain reaction in blood or cerebrospinal fluid samples and further characterized by multi-locus sequence typing that defined sequence type and clonal complexes. Sequencing of gene (encoding the penicillin-binding protein 2) was also used to predict susceptibility to β-lactams.
Between July and December 2023, we identified four cases of invasive meningococcal disease among adults, with two fatal cases in Algeria. Three cases were among subjects who recently arrived in Algeria from sub-Saharan African countries and one case was reported in an autochthonal subject. A case was also detected in France in 2018 in a subject who traveled to Cameroon. All five cases were provoked by group C isolates and belonged to the clonal complex cc10217 with identical PorA (P1.21-15,16) and FetA (F1-7) markers. The sequencing revealed a wildtype allele that is correlated to susceptibility to β-lactams.
Our results suggest that serogroup C isolates belonging to cc10217 are spreading beyond the meningitis belt. The data underscore the need for enhanced surveillance to inform vaccination strategies.
监测由克隆复合体10217的C群分离株引起的侵袭性脑膜炎球菌病在撒哈拉以南非洲脑膜炎带以外地区的传播情况。
通过对血液或脑脊液样本进行实时聚合酶链反应来确诊病例，并通过多位点序列分型进一步鉴定，该分型可确定序列类型和克隆复合体。还对基因（编码青霉素结合蛋白2）进行测序，以预测对β-内酰胺类药物的敏感性。
在2023年7月至12月期间，我们在成人中发现了4例侵袭性脑膜炎球菌病病例，其中阿尔及利亚有2例死亡病例。3例病例发生在最近从撒哈拉以南非洲国家抵达阿尔及利亚的人员中，1例病例报告于一名本地居民。2018年在法国也检测到1例病例，该患者曾前往喀麦隆。所有5例病例均由C群分离株引起，属于克隆复合体cc10217，具有相同的PorA（P1.21-15,16）和FetA（F1-7）标记。基因测序显示一个与对β-内酰胺类药物敏感性相关的野生型等位基因。
我们的结果表明，属于cc10217的C群分离株正在向脑膜炎带以外地区传播。这些数据强调需要加强监测，以为疫苗接种策略提供依据。
