Kalangi Harika, Ajit Anjali Anne, Camins Bernard, Yancovitz Stanley R
Department of Medicine, Division of Infectious Diseases, Mount Sinai Morningside/West/Beth-Israel, 1111 Amsterdam Ave, New York, NY 10025, USA.
Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place Box 1090, New York, NY 10029, USA.
IDCases. 2024 Oct 15;38:e02094. doi: 10.1016/j.idcr.2024.e02094. eCollection 2024.
is a gram-negative bacterium that encompasses a diverse group of strains with varying pathogenic potentials. Classified into six serotypes (a-f), it has been historically associated with a range of infections, including respiratory tract infections, bacteremia, meningitis, and others. Of particular significance is type b (Hib), which was a leading cause of invasive diseases in children prior to the introduction of the Hib vaccine. The Hib vaccine has revolutionized the prevention of severe bacterial infections and has drastically reduced the incidence of Hib. serotype a (Hia) has now emerged as a significant contributor to bacterial meningitis leading to morbidity and mortality. It remains a notable concern among elderly patients, despite its historical association with children. This shift in demographic susceptibility is accompanied by distinct clinical characteristics and challenges in diagnosis. Here we report a case of Hia meningitis and bacteremia in a previously healthy elderly patient, who responded to ceftriaxone treatment. Efforts to address the global burden of Hia meningitis include robust surveillance and potential vaccine development, aiming to mitigate its impact on vulnerable populations.
是一种革兰氏阴性菌，包含多种具有不同致病潜力的菌株。它被分为六种血清型（a - f），历史上与一系列感染有关，包括呼吸道感染、菌血症、脑膜炎等。其中特别重要的是b型（Hib），在Hib疫苗引入之前，它是儿童侵袭性疾病的主要原因。Hib疫苗彻底改变了严重细菌感染的预防方式，并大幅降低了Hib的发病率。a型（Hia）血清型现在已成为导致发病和死亡的细菌性脑膜炎的重要病因。尽管它历史上与儿童有关，但在老年患者中仍然是一个值得关注的问题。这种人群易感性的转变伴随着独特的临床特征和诊断挑战。在此，我们报告一例既往健康的老年患者发生Hia脑膜炎和菌血症的病例，该患者对头孢曲松治疗有反应。应对Hia脑膜炎全球负担的努力包括加强监测和潜在的疫苗研发，旨在减轻其对弱势群体的影响。
