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免疫功能正常的年轻女性中伪装为子宫颈肿物的播散性结核病:一例报告

Disseminated Tuberculosis Masquerading as a Uterine Cervical Mass in an Immunocompetent Young Female: A Case Report.

作者信息

Varma Sagar, M Lakshmi, Moorthy Swathy, Bhaskar Emmanuel

机构信息

Internal Medicine, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.

出版信息

Cureus. 2024 Oct 5;16(10):e70883. doi: 10.7759/cureus.70883. eCollection 2024 Oct.

DOI:10.7759/cureus.70883
PMID:39497874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11534441/
Abstract

Concurrent tubercular involvement of two or more non-contiguous organs is termed disseminated tuberculosis (TB) and is rare in immunocompetent patients. We describe the case of a young immunocompetent woman with disseminated TB who presented with primary complaints of amenorrhea and dysuria. Abdominal ultrasound showed a uterine cervical mass, which on histopathological evaluation revealed epithelioid granulomata with Langhans giant cells and acid-fast bacilli (AFB). Her chest radiograph showed scattered air space opacities bilaterally, and contrast-enhanced computed tomography of the abdomen revealed the involvement of bilateral kidneys, para-aortic lymph nodes, adrenals, sacroiliac regions, and the gastrointestinal tract. A colonoscopy picked up an ulcer in the terminal ileum, which on histopathology was positive for AFB. The patient was started on anti-tubercular treatment.

摘要

两个或更多非相邻器官同时发生结核累及被称为播散性结核病(TB),在免疫功能正常的患者中较为罕见。我们描述了一例患有播散性结核病的年轻免疫功能正常女性病例,其主要主诉为闭经和排尿困难。腹部超声显示宫颈有肿物,经组织病理学评估发现有上皮样肉芽肿,伴有朗汉斯巨细胞和抗酸杆菌(AFB)。她的胸部X线片显示双侧散在的气腔模糊影,腹部增强计算机断层扫描显示双侧肾脏、腹主动脉旁淋巴结、肾上腺、骶髂区域和胃肠道均有累及。结肠镜检查发现回肠末端有一处溃疡,组织病理学检查显示抗酸杆菌阳性。该患者开始接受抗结核治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81eb/11534441/0b7a4ceb345a/cureus-0016-00000070883-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81eb/11534441/74f39f20bd63/cureus-0016-00000070883-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81eb/11534441/0b7a4ceb345a/cureus-0016-00000070883-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81eb/11534441/74f39f20bd63/cureus-0016-00000070883-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81eb/11534441/0b7a4ceb345a/cureus-0016-00000070883-i03.jpg

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本文引用的文献

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Imaging Manifestations of Genitourinary Tuberculosis.泌尿生殖系统结核的影像学表现
Radiographics. 2021 Jul-Aug;41(4):1123-1143. doi: 10.1148/rg.2021200154. Epub 2021 May 28.
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Miliary tuberculosis: A new look at an old foe.粟粒性肺结核:对老对手的新审视。
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Urogenital tuberculosis - epidemiology, pathogenesis and clinical features.泌尿生殖系统结核病 - 流行病学、发病机制和临床特征。
Nat Rev Urol. 2019 Oct;16(10):573-598. doi: 10.1038/s41585-019-0228-9. Epub 2019 Sep 23.
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Genital tuberculosis in females.女性生殖器结核。
Indian J Med Res. 2017 Apr;145(4):425-436. doi: 10.4103/ijmr.IJMR_1550_15.
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Patients with secondary amenorrhea due to tuberculosis endometritis towards the induced anti-tuberculosis drug category 1.因结核性子宫内膜炎导致继发性闭经的患者对一线抗结核药物的反应情况。 (你提供的原文似乎不太完整或准确,正常理解下这句话可能不是很通顺,这是根据字面尽量贴近原意的翻译)
Pan Afr Med J. 2016 Jun 7;24:121. doi: 10.11604/pamj.2016.24.121.9709. eCollection 2016.
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Tuberculosis of the genitourinary system-Urinary tract tuberculosis: Renal tuberculosis-Part II.泌尿生殖系统结核 - 泌尿系统结核:肾结核 - 第二部分
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Tuberculosis of the genitourinary system-Urinary tract tuberculosis: Renal tuberculosis-Part I.泌尿生殖系统结核 - 泌尿系统结核:肾结核 - 第一部分
Indian J Radiol Imaging. 2013 Jan;23(1):46-63. doi: 10.4103/0971-3026.113615.
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J Clin Diagn Res. 2013 Jun;7(6):1189-90. doi: 10.7860/JCDR/2013/5460.3077. Epub 2013 Jun 1.
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Tuberculosis (Edinb). 2010 Nov;90(6):361-6. doi: 10.1016/j.tube.2010.08.005. Epub 2010 Sep 9.