Ando Mutsumi, Taki Iori, Yamazaki Taigi, Hida Noriko
Division of Clinical Research and Development, Graduate School of Pharmacy, Showa University, Setagaya-ku, Japan.
Department of Clinical Pharmacy, Division of Clinical Research and Development, School of Pharmacy, Showa University, Setagaya-ku, Japan.
Front Psychiatry. 2024 Oct 21;15:1431604. doi: 10.3389/fpsyt.2024.1431604. eCollection 2024.
Developmental disabilities (DD) often persist into adulthood, necessitating early and continuous treatment. Although pharmacotherapy is a viable treatment option, managing medication can be challenging. Prior research has not explored medication use among patients with DD in Japan. Thus, this study aimed to identify the medication challenges faced by these patients.
A questionnaire survey was administered to 200 outpatients to collect data on the number of prescribed medications, the timing of administration, the frequency of missed doses, and the use of medication notebooks. This was a prospective observational study without intervention and a random sampling.
The survey revealed that 57.0% of the participants were non-adherent to their medication regimen. Specifically, medication non-adherence rates were 44.7% among individuals with autism spectrum disorder (ASD), 86.9% for those with attention deficit hyperactivity disorder (ADHD), and 30.4% for patients with comorbid ASD and ADHD. Despite 48.3% of the participants taking measures to prevent forgetting their medication, 65.3% of them still failed to take their medication as prescribed. The possession rate of medication record books was 96.0%.
The study indicates that the frequency of medication non-adherence among patients with DD in Japan mirrors that in other countries. Patients who reported taking preventative measures still experienced high rates of non-adherence, suggesting limited effectiveness of these strategies. It is essential to develop more effective measures to improve adherence, enhance disease awareness, and increase understanding of medication instructions. The high possession rate of medication record books suggests they could play a significant role in managing DD, and their use is expected to increase in the future.
发育障碍（DD）常常会持续到成年期，因此需要早期且持续的治疗。尽管药物治疗是一种可行的治疗选择，但管理药物可能具有挑战性。先前的研究尚未探讨日本发育障碍患者的用药情况。因此，本研究旨在确定这些患者面临的用药挑战。
对200名门诊患者进行问卷调查，以收集关于处方药数量、给药时间、漏服频率以及用药笔记本使用情况的数据。这是一项无干预的前瞻性观察性研究，采用随机抽样。
调查显示，57.0%的参与者未坚持用药方案。具体而言，自闭症谱系障碍（ASD）患者的用药不依从率为44.7%，注意力缺陷多动障碍（ADHD）患者为86.9%，患有ASD和ADHD共病的患者为30.4%。尽管48.3%的参与者采取措施防止忘记服药，但其中65.3%的人仍未按规定服药。用药记录册的拥有率为96.0%。
该研究表明，日本发育障碍患者的用药不依从频率与其他国家相似。报告采取预防措施的患者仍有较高的不依从率，这表明这些策略的效果有限。必须制定更有效的措施来提高依从性、增强疾病意识并增进对用药说明的理解。用药记录册的高拥有率表明它们在发育障碍管理中可能发挥重要作用，预计其使用在未来会增加。
