Li Mengyuan, Mu Baohui, Li Mengmeng, Zhang Xinyu, Zhang Jing, Huang Haipeng, Wang Hongfeng
Institute of Acupuncture and Massage, Northeast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China.
Changchun University of Chinese Medicine, Changchun, Jilin, China.
Heliyon. 2024 Oct 16;10(20):e39059. doi: 10.1016/j.heliyon.2024.e39059. eCollection 2024 Oct 30.
Research has started using Magnetic Resonance Imaging (MRI) to elucidate the action of acupuncture on neuroplasticity following ischemic stroke (IS). Acupuncture is thought to be a potentially beneficial treatment for IS. However, the results remain inconsistent because of MRI processing techniques and study design variations. Therefore, this coordinate-based meta-analysis and systematic review aimed to assess the current state of knowledge about the regional brain fMRI imaging characteristics in acupuncture-treated IS patients. Twenty studies-including 392 IS patients and 256 health controls-met the inclusion criteria after searches via Chinese and English databases. The design techniques utilized in this research were mainly owned before-and-after controlled and randomized controlled trials. Only one study used independent component analysis (ICA), while the majority of MRI analytical techniques focus on functional connectivity (FC) and fractional amplitude of low-frequency fluctuation (fALFF/ALFF). The findings demonstrated a significant rise in the ALFF value of the left supplementary motor region after treatment with acupuncture. The left cerebellum, right inferior frontal gyrus, and hemisphere lobule VIII all showed substantial activation of Reho values. The triangular portion, BA 48, the left inferior network and inferior longitudinal fasciculus, as well as other brain areas decreased in the left inferior frontal gyrus; most research has used FC analysis employing motor areas as seed regions. We found that acupuncture regulated the motor-related network and reorganized the language-related network. Furthermore, acupuncture appears therapeutic for several IS effects, which may be connected to how acupuncture regulates the brain's plasticity.
研究已开始使用磁共振成像（MRI）来阐明针刺对缺血性中风（IS）后神经可塑性的作用。针刺被认为是一种对IS可能有益的治疗方法。然而，由于MRI处理技术和研究设计的差异，结果仍然不一致。因此，这项基于坐标的荟萃分析和系统评价旨在评估针刺治疗IS患者脑功能磁共振成像（fMRI）区域成像特征的现有知识状态。通过中英文数据库检索后，20项研究（包括392例IS患者和256例健康对照）符合纳入标准。本研究采用的设计技术主要为前后对照试验和随机对照试验。只有一项研究使用了独立成分分析（ICA），而大多数MRI分析技术侧重于功能连接（FC）和低频振幅分数（fALFF/ALFF）。研究结果表明，针刺治疗后左侧辅助运动区的ALFF值显著升高。左侧小脑、右侧额下回和半球小叶VIII的Reho值均显示出显著激活。左侧额下回的三角部、BA48、左侧下网络和下纵束以及其他脑区减少；大多数研究使用以运动区为种子区域的FC分析。我们发现针刺调节了运动相关网络并重组了语言相关网络。此外，针刺似乎对几种IS效应具有治疗作用，这可能与针刺调节大脑可塑性的方式有关。
