对于顺铂不耐受的转移性阴茎癌患者，化疗中用卡铂替代顺铂。

Switching cisplatin to carboplatin in chemotherapy for metastatic penile cancer in a patient intolerant to cisplatin.

作者信息

Sekine Keita, Suyama Takahito, Takei Kazuki, Kato Hiroto, Wakai Ken, Okato Atsushi, Hou Kyokushin, Araki Kazuhiro, Yamazaki Kazuto, Naya Yukio

机构信息

Department of Urology Teikyo University Chiba Medical Center Ichihara Chiba Japan.

Present address: Chibaken Saiseikai Narashino Hospital Chiba Japan.

出版信息

IJU Case Rep. 2024 Aug 21;7(6):434-437. doi: 10.1002/iju5.12772. eCollection 2024 Nov.

INTRODUCTION

Cisplatin is currently the key drug in the chemotherapy regimen for metastatic penile cancer. There are few reports of alternative medicines for patients who cannot tolerate cisplatin. This report describes a case in which carboplatin was used instead.

CASE PRESENTATION

The patient presented with a chief complaint of edema in the groin area. On close examination, penile cancer (cT2-3N3M0 stage IV) with pelvic lymph node metastasis was diagnosed. He was started on chemotherapy with cisplatin (50 mg/m on days 1 and 2), paclitaxel (120 mg/m on day 1), and 5-fluorouracil (1000 mg/m on days 2-5), but he developed acute kidney failure on the 12th day, thought to be caused by cisplatin. Cisplatin was changed to carboplatin, and chemotherapy was continued. He has received nine courses of chemotherapy and is doing well.

CONCLUSION

A case of penile cancer safely and effectively treated with chemotherapy using carboplatin was reported.

引言

顺铂是目前转移性阴茎癌化疗方案中的关键药物。对于无法耐受顺铂的患者，替代药物的报道较少。本报告描述了一例使用卡铂替代顺铂的病例。

病例介绍

患者以腹股沟区水肿为主诉就诊。经仔细检查，诊断为阴茎癌（IV期，cT2 - 3N3M0）伴盆腔淋巴结转移。他开始接受顺铂（第1天和第2天，50mg/m²）、紫杉醇（第1天，120mg/m²）和5-氟尿嘧啶（第2 - 5天，1000mg/m²）的化疗，但在第12天出现急性肾衰竭，认为是由顺铂引起的。顺铂改为卡铂，并继续化疗。他已接受了九个疗程的化疗，目前情况良好。