Liang YangYang, Zhang QingQing, Fan YouFei
Department of Sports Trauma and Arthroscopic Surgery, The Affiliated Bozhou Hospital of Anhui Medical University, Bozhou, China.
Department of Respiratory and Critical Care Medicine, The Affiliated Bozhou Hospital of Anhui Medical University, Bozhou, China.
Front Pharmacol. 2024 Oct 21;15:1493155. doi: 10.3389/fphar.2024.1493155. eCollection 2024.
Anterior cruciate ligament (ACL) injury is a common sports injury, and ACL reconstruction is an effective surgery for this trauma. Most cases gain good recovery after surgery, while some patients may experience knee stiffness, which is characterized by joint fibrosis, leading to reduced joint mobility, pain, and dysfunction. Currently, various research studies have been conducted to unveil the mechanisms underlying this condition, identifying pre-, intra-, and post-operative risk factors, and testify the efficacy of different therapeutic methods against it. In this review, we summarize the current progress regarding the advancements in knee fibrosis after ACL reconstruction. The risk factors associated with knee fibrosis are systematically delineated, accompanied by an evaluation of the efficacy of various treatment modalities for both the prevention and mitigation of fibrosis. Furthermore, recommendations for future research directions are proposed, offering a foundational basis for subsequent investigations.
前交叉韧带（ACL）损伤是一种常见的运动损伤，ACL重建是针对这种创伤的有效手术。大多数病例术后恢复良好，而一些患者可能会出现膝关节僵硬，其特征为关节纤维化，导致关节活动度降低、疼痛和功能障碍。目前，已经开展了各种研究来揭示这种情况的潜在机制，确定术前、术中和术后的风险因素，并验证不同治疗方法对其的疗效。在本综述中，我们总结了ACL重建术后膝关节纤维化进展的当前研究成果。系统地阐述了与膝关节纤维化相关的风险因素，并评估了各种治疗方式在预防和减轻纤维化方面的疗效。此外，还提出了未来研究方向的建议，为后续研究提供了基础依据。
