Acioly Patrícia Medeiros Gusmão, Mazzillo Mara Diane Lisboa Tavares, Machado Carla Jorge, Camargo Cláudia, Penetra Maria Alice, Januário Virginia, Dos Reis Beatriz Ribeiro, Ramos-E-Silva Marcia, Carneiro Sueli
Sector of Dermatology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Postgraduation Program in Medical Clinics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Psoriasis (Auckl). 2024 Oct 31;14:123-130. doi: 10.2147/PTT.S471707. eCollection 2024.
There is a growing body of evidence suggesting the association between psoriasis (PsO) and psoriatic arthritis (PsA) separately with metabolic syndrome (MS) in different populations. The literature is relatively scarce in terms of comparing the prevalence of MS in PsO and PsA with controls without systemic inflammatory diseases.
We aimed to assess the prevalence of MS among patients with PsO, PsA, and a control group without systemic inflammatory disease, in addition to investigating the risks of MS occurrence and its different components in each group.
This is a cross-sectional case-control study with three groups of patients: PsO, PsA, and control. The diagnosis of MS was defined according to the modified 2009 NCTEP ATP III criteria. Patients underwent thorough physical examination and fasting blood samples.
A total of 195 patients were included in this analysis (PsO = 50; PsA = 64, and controls = 81). The prevalence of MS in the control, PsO, and PsA groups was 37%, 56%, and 57.8%, respectively (p < 0.001). Waist circumference (p = 0.013) and arterial hypertension (p < 0.001) were the most significant components of MS in patients with PsO and PsA. Multivariate analysis confirmed an independent risk of MS in women, elderly patients, obese patients, patients with hyperglycemia, and patients with psoriasis, especially PsA (OR = 6.2 [CI 95% 2.4-16.2], p < 0.001).
MS is more prevalent in patients with PsA, which can be determined by the increase in inflammatory pathways.
越来越多的证据表明，在不同人群中，银屑病（PsO）和银屑病关节炎（PsA）分别与代谢综合征（MS）之间存在关联。在比较PsO和PsA患者与无全身性炎症性疾病的对照组中MS的患病率方面，相关文献相对较少。
我们旨在评估PsO、PsA患者以及无全身性炎症性疾病的对照组中MS的患病率，此外还调查每组中MS发生的风险及其不同组分。
这是一项横断面病例对照研究，有三组患者：PsO组、PsA组和对照组。MS的诊断根据2009年修改的NCTEP ATP III标准进行定义。患者接受了全面的体格检查和空腹血样采集。
本分析共纳入195例患者（PsO组 = 50例；PsA组 = 64例，对照组 = 81例）。对照组、PsO组和PsA组中MS的患病率分别为37%、56%和57.8%（p < 0.001）。腰围（p = 0.013）和动脉高血压（p < 0.001）是PsO和PsA患者中MS最显著的组分。多变量分析证实，女性、老年患者、肥胖患者、高血糖患者以及银屑病患者尤其是PsA患者存在MS的独立风险（OR = 6.2 [95% CI 2.4 - 16.2]，p < 0.001）。
MS在PsA患者中更为普遍，这可由炎症途径的增加来确定。
