新型双膦酸对大鼠肿瘤诱导的骨破坏的影响。
Effects of new bisphosphonic acids on tumor-induced bone destruction in the rat.
作者信息
Wingen F, Eichmann T, Manegold C, Krempien B
出版信息
J Cancer Res Clin Oncol. 1986;111(1):35-41. doi: 10.1007/BF00402773.
Abstract
This report is concerned with therapeutic studies utilizing new bisphosphonic acids on tumor-induced osteolytic metastases. The bone metastases on SD rats were induced by intraarterial and intraosseous transplantation of Walker carcinosarcoma 256 B ascites cells. The treatment was carried out using disodium-3-amino-1-hydroxypropylidene-1,1-bisphosphonate (ADP), diglycidyl-[3-(3, 3-bisphosphono-3-hydroxy-propylamino)-2-hydroxypropyl-]urazol++ +-Na2 (DDU) and 1,2,4-triglycidylurazol (TGU). The extent of bone metastases was determined by X-ray on the 5th and 10th days following tumor inoculation, as well as both microradiographically and histologically upon termination of the experiment. High dose DDU produced a clear reduction of the tumor osteolysis, but these positive results were surpassed using APD. The best results were achieved by pretreatment with APD 24 h prior to tumor inoculation.
摘要
本报告涉及利用新型双膦酸治疗肿瘤诱导的溶骨性转移的研究。通过动脉内和骨内移植Walker癌肉瘤256 B腹水细胞在SD大鼠中诱导骨转移。使用3-氨基-1-羟丙基-1,1-双膦酸二钠（ADP）、二缩水甘油基-[3-(3,3-双膦酰基-3-羟丙基氨基)-2-羟丙基]-尿唑+++-Na2（DDU）和1,2,4-三缩水甘油基尿唑（TGU）进行治疗。在接种肿瘤后的第5天和第10天通过X射线测定骨转移的程度，并在实验结束时通过显微放射摄影和组织学测定。高剂量DDU可明显减少肿瘤骨溶解，但使用ADP可取得更好的效果。在接种肿瘤前24小时用ADP预处理可取得最佳效果。
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