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新加坡植入式心脏复律除颤器远程监测的长期临床结果

Long-term clinical outcomes of remote monitoring for implantable cardioverter-defibrillators in Singapore.

作者信息

Tan Vern Hsen, Fong Khi Yung, Teo Lisa Jie Ting, Lo Deborah Wai Yi, Ku Fiona Wan Qi, Chan Yiong Huak, Wang Yue, Yeo Colin, Ching Chi Keong, Lim Toon Wei

机构信息

Department of Cardiology, Changi General Hospital, Singapore.

Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

出版信息

Singapore Med J. 2024 Nov 5. doi: 10.4103/singaporemedj.SMJ-2024-058.

DOI:10.4103/singaporemedj.SMJ-2024-058
PMID:39498527
Abstract

INTRODUCTION

Remote monitoring (RM) for cardiac implantable electronic devices is on the rise and has been shown to reduce the burden of in-clinic follow-up visits. We aimed to investigate the long-term clinical outcomes of RM versus no RM.

METHODS

This was a prospective, single-centre cohort study of consecutive patients with an implantable cardioverter-defibrillator (ICD) or cardiac resynchronisation therapy-defibrillator (CRT-D) followed up from 2018 to 2023. Patients who received non-ICD devices were excluded. In general, RM was offered to all patients, but uptake depended on patient preference. For data analysis, patients were stratified according to whether RM was used. The primary outcome was all-cause mortality; secondary outcomes were hospitalisation for heart failure and device therapy (shocks and electrical storm).

RESULTS

Of 551 patients, 284 (51.5%) received RM and 267 (49.5%) did not. Baseline demographics were similar between the two arms. All-cause mortality was significantly lower in RM versus non-RM patients (hazard ratio [HR] 0.45, 95% confidence interval [CI] 0.33-0.60, P <0.001), as was hospitalisation for heart failure (HR 0.39, 95% CI 0.25-0.59, P <0.001); these remained significant after adjustment for baseline covariates. More patients on RM received appropriate antitachycardia pacing (ATP) (17.6% vs. 10.7%, P = 0.035) and appropriate shocks (24.1% vs. 14.7%, P = 0.017). The incidences of inappropriate ATP, inappropriate shocks and electrical storm were similar. More patients on RM underwent pulse generator change (34.1% vs. 10.1%, P <0.001).

CONCLUSION

Remote monitoring was associated with significantly lower mortality in both ICDs and CRT-Ds and in primary and secondary indications, as well as fewer heart failure hospitalisations. This supports current guidelines recommending the use of RM in all patients with ICD or CRT-D.

摘要

引言

心脏植入式电子设备的远程监测(RM)正在兴起,并且已被证明可减轻门诊随访负担。我们旨在研究RM与非RM的长期临床结局。

方法

这是一项对2018年至2023年连续纳入的植入式心律转复除颤器(ICD)或心脏再同步化治疗除颤器(CRT-D)患者进行的前瞻性单中心队列研究。接受非ICD设备的患者被排除。一般而言,所有患者均可接受RM,但接受情况取决于患者偏好。为进行数据分析,患者根据是否使用RM进行分层。主要结局是全因死亡率;次要结局是因心力衰竭住院和设备治疗(电击和电风暴)。

结果

551例患者中,284例(51.5%)接受了RM,267例(49.5%)未接受。两组的基线人口统计学特征相似。RM患者的全因死亡率显著低于非RM患者(风险比[HR]0.45,95%置信区间[CI]0.33 - 0.60,P<0.001),因心力衰竭住院率也是如此(HR 0.39,95%CI 0.25 - 0.59,P<0.001);在对基线协变量进行调整后,这些结果仍然显著。更多接受RM的患者接受了适当的抗心动过速起搏(ATP)(17.6%对10.7%,P = 0.035)和适当的电击(24.1%对14.7%,P = 0.017)。不适当ATP、不适当电击和电风暴的发生率相似。更多接受RM的患者进行了脉冲发生器更换(34.1%对10.1%,P<0.001)。

结论

远程监测与ICD和CRT-D患者以及主要和次要适应症患者的死亡率显著降低相关,同时心力衰竭住院次数减少。这支持了当前指南推荐在所有ICD或CRT-D患者中使用RM的建议。

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