Design, Synthesis, and Biological Activity Studies of Myricetin Derivatives Containing a Diisopropanolamine Structure.

A series of myricetin derivatives containing diisopropanolamine were designed and synthesized. The in vitro inhibitory effects of the target compounds on 9 fungal pathogens and 3 bacterial pathogens were also evaluated. had the best inhibitory effect against (), with an EC value of 4.9 μg/mL, which was better than zinc-thiazole (ZT: EC = 7.3 μg/mL) and thiodiazole-copper (TC: EC = 65.5 μg/mL); had the best inhibitory effect against . (), with an EC value of 17.2 μg/mL, which was better than azoxystrobin (Az: EC = 22.3 μg/mL). In vivo inhibition tests were performed on kiwifruit for and rice leaves for . At 200 μg/mL, the curative activity of against rice leaf blight was 40.7%, which was better than that of ZT (37.2%) and TC (32.9%), and the protective activity of was 44.8%, which was better than that of ZT (39.5%) and TC (34.6%). The curative activity of against kiwi soft rot disease was 70.1%, which was better than that of Az (62.8%). Preliminary elucidation of the possible mechanisms of action was carried out by experiments on fluorescence microscopy, scanning electron microscopy, formation of biofilms, density functional theory calculations, and so on.