Kapellas Nikolaos, Alkhalil Samer, Senkal Metin
Marien Hospital Witten, Witten, Germany.
Obes Surg. 2024 Dec;34(12):4563-4572. doi: 10.1007/s11695-024-07571-0. Epub 2024 Nov 5.
This study aimed to investigate the efficacy of one-anastomosis gastric bypass (OAGB) on gastroesophageal reflux disease (GERD) compared with Roux-en-Y gastric bypass (RYGB) in patients with obesity. Three databases (Medline, Cochrane Central, and Scopus) were searched for relevant articles published until August 12, 2024. A total of nine randomized controlled trials, including 643 patients, were selected. OAGB was statistically significantly associated with a higher risk of GERD than RYGB (OR = 3.14, 95% CI 1.23-8.03, p < 0.05). The odds for de novo GERD after OAGB are almost six times higher than after RYGB (OR = 5.65, 95% CI 1.53-20.82, p < 0.05). RYGB has a lower incidence of de novo GERD cases and is more effective than OAGB in reducing GERD.
本研究旨在探讨在肥胖患者中，单吻合口胃旁路术（OAGB）与 Roux-en-Y 胃旁路术（RYGB）相比，对胃食管反流病（GERD）的疗效。检索了三个数据库（Medline、Cochrane 中心和 Scopus），查找截至 2024 年 8 月 12 日发表的相关文章。共纳入九项随机对照试验，包括 643 名患者。与 RYGB 相比，OAGB 与 GERD 风险较高在统计学上具有显著相关性（OR = 3.14，95%CI 1.23 - 8.03，p < 0.05）。OAGB 术后新发 GERD 的几率几乎是 RYGB 术后的六倍（OR = 5.65，95%CI 1.53 - 20.82，p < 0.05）。RYGB 新发 GERD 病例的发生率较低，在减轻 GERD 方面比 OAGB 更有效。
