整合围手术期特征与移植肝内TCF7L2表达以预测肝移植受者的脂质代谢紊乱 - Suppr

Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients.

作者信息

Zhou Junbin, Wei Rongli, Fan Guanghan, Lian Zhengxing, Zhang Xuanyu, Tang Linsong, Qi Zhetuo, Xie Haiyang, Zheng Shusen, Wei Qiang, Xu Xiao

机构信息

Department of Hepatobiliary and Pancreatic Surgery, People's Hospital of Lishui, Affiliated Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui, 323000, China.

NHFPC Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, 310003, China.

出版信息

Sci China Life Sci. 2025 Jan;68(1):297-299. doi: 10.1007/s11427-024-2590-x. Epub 2024 Oct 31.

DOI:10.1007/s11427-024-2590-x

PMID:39499443

Abstract

摘要

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Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients.整合围手术期特征与移植肝内TCF7L2表达以预测肝移植受者的脂质代谢紊乱

Sci China Life Sci. 2025 Jan;68(1):297-299. doi: 10.1007/s11427-024-2590-x. Epub 2024 Oct 31.

Costimulatory blockade prevents early rejection, promotes lymphocyte apoptosis, and inhibits the upregulation of intragraft interleukin-6 in an orthotopic liver transplant model in the rat.共刺激阻断可预防大鼠原位肝移植模型中的早期排斥反应，促进淋巴细胞凋亡，并抑制移植肝内白细胞介素-6的上调。

Liver Transpl. 2002 May;8(5):458-68. doi: 10.1053/jlts.2002.32979.

TCF7L2 (rs7903146) But Not CDKAL1 (rs7754840) Gene Polymorphisms Increase the Risk of New-Onset Diabetes After Kidney Transplant.TCF7L2（rs7903146）而非 CDKAL1（rs7754840）基因多态性增加肾移植后新发糖尿病的风险。

Exp Clin Transplant. 2023 Nov;21(11):872-878. doi: 10.6002/ect.2020.0335. Epub 2021 Feb 24.

Intragraft gene and protein expression in rat liver allografts treated with costimulatory blockade alone or in combination with CyA.单独或联合环孢素A进行共刺激阻断处理的大鼠肝脏同种异体移植中移植物内的基因和蛋白质表达。

J Surg Res. 2003 Nov;115(1):1-8. doi: 10.1016/s0022-4804(03)00131-8.

Analysis of alloreactivity and intragraft cytokine profiles in living donor liver transplant recipients with graft acceptance.对接受活体供肝移植且移植肝存活的受者的同种异体反应性及移植肝内细胞因子谱进行分析。

Transpl Immunol. 2001 Feb;8(4):279-86. doi: 10.1016/s0966-3274(01)00027-2.

Polymorphism of Transcription Factor-7-Like 2 (TCF7L2) Gene and New-Onset Diabetes after Liver Transplantation.转录因子7样蛋白2（TCF7L2）基因多态性与肝移植术后新发糖尿病

Int J Organ Transplant Med. 2015;6(1):14-22.

TCF7L2 transcriptionally regulates Fgf15 to maintain bile acid and lipid homeostasis through gut-liver crosstalk.TCF7L2 通过肠-肝串扰转录调控 Fgf15 以维持胆汁酸和脂质稳态。

FASEB J. 2022 Mar;36(3):e22185. doi: 10.1096/fj.202101607R.

T cell receptor repertoires within liver allografts are different to those in the peripheral blood.肝移植受者体内的T细胞受体谱与外周血中的不同。

J Hepatol. 2021 May;74(5):1167-1175. doi: 10.1016/j.jhep.2020.12.014. Epub 2020 Dec 18.

Tcf7l2 in hepatocytes regulates de novo lipogenesis in diet-induced non-alcoholic fatty liver disease in mice.肝细胞中的 Tcf7l2 调控饮食诱导的非酒精性脂肪性肝病小鼠模型中的从头脂肪生成。

Diabetologia. 2023 May;66(5):931-954. doi: 10.1007/s00125-023-05878-8. Epub 2023 Feb 10.

Attenuation of allograft rejection by intragraft inhibition of class II transcativator in high responder rat liver transplantation.高反应性大鼠肝移植中通过移植物内抑制II类反式激活因子减轻同种异体移植排斥反应

Microsurgery. 2015 Jan;35(1):52-9. doi: 10.1002/micr.22265. Epub 2014 Apr 25.

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Cancer profiles in China and comparisons with the USA: a comprehensive analysis in the incidence, mortality, survival, staging, and attribution to risk factors.中国癌症概况及与美国的比较：发病率、死亡率、生存率、分期和归因于危险因素的综合分析。

Sci China Life Sci. 2024 Jan;67(1):122-131. doi: 10.1007/s11427-023-2423-1. Epub 2023 Sep 21.

Liver transplantation in patients with liver failure: Twenty years of experience from China.肝衰竭患者的肝移植：来自中国的 20 年经验。

Liver Int. 2022 Aug;42(9):2110-2116. doi: 10.1111/liv.15288. Epub 2022 May 16.

PEG35 and Glutathione Improve Mitochondrial Function and Reduce Oxidative Stress in Cold Fatty Liver Graft Preservation.聚乙二醇35和谷胱甘肽改善冷保存脂肪肝移植物的线粒体功能并减轻氧化应激。

Antioxidants (Basel). 2022 Jan 14;11(1):158. doi: 10.3390/antiox11010158.

Risk factors for the metabolic syndrome components of hypertension, diabetes mellitus, and dyslipidemia after living donor liver transplantation.活体肝移植后高血压、糖尿病和血脂异常代谢综合征成分的危险因素。

HPB (Oxford). 2020 Apr;22(4):511-520. doi: 10.1016/j.hpb.2019.08.008. Epub 2019 Sep 24.

Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism.脂肪细胞特异性敲除 Tcf7l2 促进脂肪细胞肥大和葡萄糖代谢受损。

Mol Metab. 2019 Jun;24:44-63. doi: 10.1016/j.molmet.2019.03.003. Epub 2019 Mar 14.

Phenothiazines Enhance the Hypothermic Preservation of Liver Grafts: A Pilot in Vitro Study.吩噻嗪增强肝脏移植物的低温保存效果：一项初步的体外研究。

Cell Transplant. 2019 Mar;28(3):318-327. doi: 10.1177/0963689718824559. Epub 2019 Jan 22.

Effect of the Selective NLRP3 Inflammasome Inhibitor mcc950 on Transplantation Outcome in a Pig Liver Transplantation Model With Organs From Donors After Circulatory Death Preserved by Hypothermic Machine Perfusion.低温机器灌注保存的体外循环死亡供体猪肝移植模型中选择性 NLRP3 炎性体抑制剂 MCC950 对移植结局的影响。

Transplantation. 2019 Feb;103(2):353-362. doi: 10.1097/TP.0000000000002461.

Metabolic complications in liver transplant recipients.肝移植受者的代谢并发症

World J Gastroenterol. 2016 Jul 28;22(28):6416-23. doi: 10.3748/wjg.v22.i28.6416.

The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells.TCF7L2在肝细胞中对全基因组靶基因的调控机制。

Nucleic Acids Res. 2014 Dec 16;42(22):13646-61. doi: 10.1093/nar/gku1225. Epub 2014 Nov 20.

Association between donor and recipient TCF7L2 gene polymorphisms and the risk of new-onset diabetes mellitus after liver transplantation in a Han Chinese population.供体和受体 TCF7L2 基因多态性与汉族人群肝移植后新发糖尿病的风险关联。

J Hepatol. 2013 Feb;58(2):271-7. doi: 10.1016/j.jhep.2012.09.025. Epub 2012 Oct 4.

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Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients.

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