Cui Gang, Xue Song, Wang Xiaoshan, Song Wei
College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, 16369, Jingshi Road Jinan City, Shandong Province, 250014, China.
Department of Minimally Invasive Oncology Treatment, Shandong Provincial Hospital of Shandong First Medical University, 324 Jingwu Weiqi Road, Jinan City, Shandong Province, 250021, China.
Postgrad Med J. 2025 May 18;101(1196):497-503. doi: 10.1093/postmj/qgae149.
Glioblastoma (GBM) is a malignant tumor of the nervous system, which is difficult to treat due to its strong invasiveness, rapid progression, and poor prognosis. To understand the complex biological behavior of glioblasts and the interaction between tumors and hosts, a new in vitro platform based on human cells is required, which can summarize the complex cellular structure and cell diversity of the human brain, as well as the biological behavior of GBM. Organoids are 3D self-organizing tissues, partially similar to source tissues, which can simulate the structure and physiological functions of organs or tissues in vitro. In this review, we underline the widespread application of different types of GBOs models in GBM pathogenesis, including cells derived, tumor tissues derived, and other co-culture models, as well as their application and shortcomings in the treatment of GBM.
胶质母细胞瘤（GBM）是一种神经系统恶性肿瘤，由于其侵袭性强、进展迅速且预后不良，难以治疗。为了了解胶质母细胞的复杂生物学行为以及肿瘤与宿主之间的相互作用，需要一个基于人类细胞的新型体外平台，该平台能够概括人类大脑复杂的细胞结构和细胞多样性，以及胶质母细胞瘤的生物学行为。类器官是三维自组织组织，部分类似于来源组织，能够在体外模拟器官或组织的结构和生理功能。在本综述中，我们强调了不同类型的胶质母细胞瘤类器官（GBO）模型在胶质母细胞瘤发病机制中的广泛应用，包括细胞来源、肿瘤组织来源以及其他共培养模型，以及它们在胶质母细胞瘤治疗中的应用和缺点。
